| 摘要: |
| 目的:对脑钠肽与心房颤动患者成功电复律后复发的关系进行meta分析。方法:查阅Medline数据库、PubMed数据库、CNKI全文数据库1980年1月至2008年1月公开发表的文章,并辅以手工检索,采用RevMan4.2软件对纳入的试验结果进行meta分析。结果:共纳入7篇文献资料,Meta分析结果表明心房颤动复发组脑钠肽浓度高于窦性心律维持组(SMD=0.82,95%CI 0.12~1.52),对总体效应进行假设检验得Z值为2.30,差异有统计学意义(P=0.02)。结论:成功电复律后脑钠肽浓度高的心房颤动患者易复发,脑钠肽可作为心房颤动复发的预测指标之一。 |
| 关键词: 脑钠肽 心房颤动 电复律 meta分析 |
| DOI：10.3724/SP.J.1008.2008.01487 |
| 投稿时间：2008-03-06修订日期：2008-03-29 |
| 基金项目:国家自然科学基金重点项目(30330290),海外青年学者合作研究基金(30528011). |
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| Relationship between brain natriuretic peptide and recurrence of atrial fibrillation after successful electrical cardioversion:a meta analysis |
| TANG Yong-qing△,GAO Yuan-jian△,CHEN Yi-han*,CHEN Yi-han* |
| (Department of Cardiology,Tongji Hospital,Tongji University,Shanghai 200065,China) |
| Abstract: |
| Objective:To examine the relationship between brain natriuretic peptide (BNP) and the recurrence of atrial fibrillation (AF) after successful electrical cardioversion (EC) by a meta analysis approach.Methods: Based on PubMed,Medline and China National Knowledge Infrastructure (CNKI) databases,related literatures,published from 1980-2008,were searched; a manual search was also performed.The included trials were analyzed by RevMan4.2 software for meta analysis.Results: Totally seven studies were finally included.The analysis revealed that the baseline BNP level were greater in patients with AF recurrence than those without AF recurrence,with the standardized mean difference in the BNP levels being 0.82 units (95% confidence interval 0.12 to 1.52).The test for overall effect Z-score was 2.30,with a P value of 0.02; there was significant difference.Conclusion: It is suggested that the higher BNP level after successful electrical cardioversion is associated with greater risk of AF recurrence.The level of BNP may serve as an indicator for AF recurrence after successful EC. |
| Key words: brain natriuretic peptide atrial fibrillation electrical cardioversion meta-analysis |
