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| CYP1A1和NAT2基因多态性与肾癌易感性关系的病例对照研究 |
| 王国萍,张鹏,许敏,常文军,刘世建,张宏伟,曹广文*,曹广文 |
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| (第二军医大学卫生勤务学系流行病学教研室,上海 200433;第二军医大学卫勤系流行病学教研室) |
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| 摘要: |
| 目的:探讨致癌物CYP1A1和NAT2基因多态性对肾癌易感性的影响。方法:利用限制性片段长度多态性-聚合酶链反应(RFLP-PCR)方法,检测病例和对照组细胞色素P450酶基因CYP1A1 MspⅠ位点和N-乙酰基转移酶2(NAT2)基因的多态性情况。 结果:与对照组相比，病例组CYP1A1 (W/M)及NAT2 (intermediate)基因型分布差异均存在统计学意义(P<0.05)。携带CYP1A1(W/M)或NAT2(intermediate)基因型的个体患肾癌的危险度升高,比值比(OR)分别达到2.487(1.493~4.142)和1.970(1.128~3.442)。多因素分析结果显示携带CYP1A1 (W/M)及NAT2(intermediate)基因型的吸烟个体具有肾癌易感性。结论:CYP1A1 (W/M)和NAT2(intermediate)基因型均是肾癌的危险因素,两者存在交互作用,且均与吸烟有协同作用。 |
| 关键词: 细胞色素P4501A1 N-乙酰基转移酶2 多态性 肾肿瘤 遗传易感性 |
| DOI：10.3724/SP.J.1008.2008.00 |
| 投稿时间：2008-03-31修订日期：2008-08-15 |
| 基金项目:国家自然科学基金(30571609). |
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| Case-control study genetic polymorphisms in CYP1A1 and NAT2 and susceptibility to renal cancer |
| WANG Guo-ping，ZHANG Peng，XU Min， CHANG Wen-jun，LIU Shi-jian，ZHANG Hong-wei, CAO Guang-wen*,caoguangwen |
| (Department of Epidemiology，Faculty of Health Service，Second Military Medical University，Shanghai 200433，China) |
| Abstract: |
| Objective:To study the effect of genetic polymorphisms of cytochrome P4501A1 (CYP1A1), N-acetyltransferase 2 (NAT2) on the susceptibility to renal cancer.Methods: The genetic polymorphisms of CYP1A1 and NAT2 were examined in the renal cancer patients and controls using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) methods.Results: The distribution of CYP1A1 (W/M) and NAT2 (intermediate) genotypes was significantly different between the renal cancer patients and controls (P<0.05).Individuals carrying CYP1A1 (W/M) or NAT2 (intermediate) genotypes had an increased risk for renal cancer（OR=2.487, 95% CI: 1.493-4.142; OR=1.970, 95% CI:1.128-3.442，respectively). Multivariate analysis showed increased risk for renal cancer patients carrying CYP1A1 (W/M) or NAT2 (intermediate) genotypes and those who smoke.Conclusion: The genotypes CYP1A1 (W/M) and NAT2 (intermediate) are the risk factors of renal cancer, and the 2 genotypes have a interactive effect and both have a joint effect with smoking. |
| Key words: cytochrome P-450 1A1 N-acetyltransferase-2 polymorphism renal cancer genetic susceptibility |
