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CXCL12/CXCR4在涎腺腺样囊性癌及周围神经组织中的表达
孟志兵1,2,徐晓刚1*,周中华1*
0
(1.第二军医大学长海医院口腔科,上海 200433;2.江苏省扬州市第一人民医院口腔科,扬州 225001)
摘要:
目的:探讨趋化因子CXCL12及其受体CXCR4与涎腺腺样囊性癌嗜神经侵袭之间的关系。方法:涎腺腺样囊性癌病例标本41例,舌癌病例标本30例,腮腺多形性腺瘤病例标本20例,正常神经组织标本20例。所有标本均制成4 μm厚的切片。应用EnVision法检测CXCR4在腺样囊性癌肿瘤组织内的表达以及CXCL12在周围神经组织内的表达。结果:腺样囊性癌癌组织内CXCR4阳性表达率为63.41%,显著高于舌癌(36.67%)及多形性腺瘤(35%) (P<0.05);周围神经组织内CXCL12高表达 (64.38%),在腺样囊性癌内的神经组织与舌癌内的神经组织及正常神经组织中CXCL12阳性率无显著差异。 结论:趋化因子受体CXCR4在腺样囊性癌中高表达,趋化因子CXCL12在周围神经组织内高表达,提示CXCL12/CXCR4可能在腺样囊性癌嗜神经侵袭中发挥重要作用。
关键词:  涎腺肿瘤  腺样囊性癌  趋化因子  受体  神经侵袭
DOI:10.3724/SP.J.1008.2008.00639
投稿时间:2008-04-09修订日期:2008-05-13
基金项目:国家自然科学基金 (30672330).
Expression of CXCL12 and CXCR4 in salivary adenoid cystic carcinoma and peripheral nerve tissues
MENG Zhi-bing1,2,XU Xiao-gang1*,ZHOU Zhong-hua1*
(1.Department of Stomatology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China;2.Department of Stomatology,The First People’s Hospital of Yangzhou,Yangzhou 225001)
Abstract:
Objective:To study the relationship between CXCL12/CXCR4 expression and the neural invasion of salivary adenoid cystic carcinoma (SACC).Methods: Totally 41 SACC specimens,30 tongue cancer specimens,20 pleomorphic adenoma specimens and 20 normal nerve specimens were included in the present study.The specimens were made into sections of 4 μm and EnVision method was used to detect the expression of the chemokine receptor CXCR4 in SACC sections and the expression of the chemokine CXCL12 in the peripheral nerve tissue sections.Results: The chemokine receptor was highly expressed in ACC cells.The positive rate of CXCR4 was 63.41% in the SACC sections,which was significantly higher than those in the tongue cancer group (36.67%) and the pleomorphic adenoma parotid group (35%) (P<0.05).The expression of CXCL12 was not significantly different between the nerve tissues of SACC,tongue cancer and the normal nerve tissues.Conclusion: The chemokine CXCL12 is elevated in the SACC cells and its receptor CXCR4 is elevated in the peripheral nerve tissues,indicating a role of the biological axis of CXCL12/CXCR4 in the neural invasion of salivary adenoid cystic carcinoma.
Key words:  salivary gland neoplasms  adenoid cystic carcinoma  chemokines  receptors  neural invasion