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多棘海盘车的化学成分
程萍1,汤华2,朴淑娟1,陆祎1,王增蕾2,林厚文1*,林厚文
0
(1.第二军医大学长征医院药学部,上海 200003*2.第二军医大学药学院海洋药物研究室,上海200433)
摘要:
目的:研究多棘海盘车正丁醇萃取部位的化学成分。 方法:利用溶媒萃取和多种色谱法,对多棘海盘车的正丁醇萃取部位化学成分进行分离,根据理化性质和现代波谱技术鉴定化合物的化学结构,并测试了其中5个化合物的生物活性。 结果:分离并鉴定了5个化合物,分别为多羟基甾体皂苷amurensoside D(Ⅰ)、色氨酸(Ⅱ)和3个硫酸甾醇,包括3β-O-硫酸酯化-6α,23β-二羟基-胆甾-9(11)-23-羰基-硫酸盐(Ⅲ)、3β-O-硫酸酯化-6α-羟基-胆甾-9(11),20(22)-二双键-23-羰基-硫酸盐(Ⅳ)和3β-O-硫酸酯化-6α-羟基-麦角甾-9(11)-双键-23-羰基-硫酸盐(Ⅴ)。 结论:化合物Ⅱ是首次从多棘海盘车中得到,化合物Ⅲ和Ⅴ对稻瘟霉菌P-2b显示较强的药理活性。
关键词:  多棘海盘车  皂苷  硫酸甾醇
DOI:10.3724/SP.J.1008.2008.01479
投稿时间:2008-05-05修订日期:2008-08-11
基金项目:国家高新技术研究发展计划(“863”计划)(2006AA09Z423);长征医院“三重三优”学科人才建设计划.
Study on chemical constituents of Starfish Asterias amurensis
CHENG Ping1,TANG Hua2,PIAO Shu-juan1,LU Yi1,WANG Zeng-lei2,LIN Hou-wen1*,LIN Hou-wen
(1.Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China*2.Department of Marine Drugs,School of Pharmacy,Second Military Medical University,Shanghai 200433)
Abstract:
Objective:To investigate the chemical constituents in the BuOH extract of Asterias amurensis.Methods: The compounds were obtained by a combination of extraction and purification with suitable solvent and multiple column chromatographies; their structures were determined based on spectral analysis and physicochemical properties.The bioactivities of 5 compounds were tested.Results: Five compounds were isolated and identified,and they were amurensoside D(Ⅰ),tryptophan Ⅱ,and 3 sulfated sterols,including 3β-O-sulfated-6α,20β-diol-cholest-9(11)-en-23-one sodium salt(Ⅲ),3β-O-sulfated-6α-ol-cholesta-9(11),20(22)-dien-23-one sodium salt(Ⅳ),and 3β-O-sulfated-6α-ol-ergost-9(11)-en-23-one sodium salt(Ⅴ).Conclusion: TryptophanⅡ is obtained from this species for the first time; compoud Ⅲ and compound Ⅴ exhibit potent inhibitory activity against Pyricularia oryzae P-2b.
Key words:  Asterias amurensis  saponin  sulfated sterols