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| 精神分裂症患者错误监控过程中激活脑区的差异 |
| 唐云翔1,2,王继军1*,张明岛1,陈兴时1,谢斌1,肖泽萍1 |
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| (1.上海交通大学医学院附属上海市精神卫生中心,上海 200030*2.第二军医大学心理学教研室,上海 200433) |
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| 摘要: |
| 目的:研究精神分裂症患者错误监控过程中激活脑区的差异。方法:使用高密度事件相关电位技术及低分辨率电磁断层扫描术,比较16例首发精神分裂症患者及25名正常对照者错误相关负电位潜伏期、波幅及脑激活部位的差异。结果:精神分裂症组的正确反应率明显低于正常对照组,正确反应和错误反应的反应时明显比正常对照组长；精神分裂症错误相关负电位潜伏期在Cz、Pz电极上较正常对照组明显延长,组错误相关负电位波幅比正常对照组低；精神分裂症组脑岛、颞上回、颞中回、顶下小叶等处激活明显低下。结论:脑岛等处的激活低下可能与精神分裂症患者错误监控功能的异常有关。 |
| 关键词: 精神分裂症 错误监控功能 事件相关电位 低分辨率电磁断层扫描术 |
| DOI：10.3724/SP.J.1008.2009.00048 |
| 投稿时间：2008-06-12修订日期：2008-11-12 |
| 基金项目:上海市浦江人才计划(06PJ14079);上海市卫生局科研基金(044031);第二军医大学青年启动基金(06QN17). |
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| Differences of activated brain areas during brain error-monitoring in schizophrenia patients |
| TANG Yun-xiang1,2,WANG Ji-jun1*,ZHANG Ming-dao1,CHEN Xing-shi1,XIE Bin1,XIAO Ze-ping1 |
| (1.Shanghai Mental Health Center,School of Medicine,Shanghai Jiaotong University,Shanghai 200030,China*2.Department of Psychology,Second Military Medical University,Shanghai 200433) |
| Abstract: |
| Objective:To study the differences of activated brain areas during brain error monitoring in schizophrenia patients.Methods: The latencies and amplitudes of error related negativity (ERN) were obtained in 16 patients with first episode schizophrenia and 25 normal controls by high-density event related potential (ERP) technique,and the activated areas were analyzed by low resolution electromagnetic tomography (LORETA).Results: The correct response rate was significantly lower in the schizophrenia participant group than in the control group (P<0.01),and the reaction periods of correct responses and incorrect responses were significantly longer in the schizophrenia group than in the control group (P<0.05,P<0.01).The ERN latencies in the schizophrenic patients were significantly longer on Cz and Pz electrodes compared with those in the control subjects (P<0.05),and ERN amplitudes were significantly smaller than those in the controls (P<0.05).The activation of insula,superior temporal gyrus,middle temporal gyrus,and inferior parietal lobule were obviously lower in the schizophrenic participants than in the controls.Conclusion: Some brain area,such as insular,may contribute to the dysfunction of error monitoring in schizophrenia patients. |
| Key words: schizophrenia error-monitoring event-related potentials low resolution electromagnetic tomography |
