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细胞黏附分子CD99与肿瘤关系的研究进展
林丽萍1,武旗2,曹广文1*
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(1.第二军医大学基础部流行病学教研室,上海200433;2.第二军医大学长海医院泌尿外科,上海200433)
摘要:
CD99分子是细胞黏附分子的一种,参与细胞黏附、凋亡过程及肿瘤细胞的迁移、浸润、侵袭,在肿瘤的发生发展过程中起重要的作用。与正常组织相比,某些肿瘤中CD99出现异常表达,这对于肿瘤的鉴别诊断、转移潜能判断、治疗和预后估计等方面有潜在的应用价值。
关键词:  CD99  肿瘤  基因
DOI:10.3724/SP.J.1008.2009.0313
投稿时间:2008-07-02修订日期:2008-11-09
基金项目:上海市教育委员会科研创新项目(08ZZ39).
Relationship between cell adhesion molecule CD99 and tumor: recent pregress
LIN Li-ping1,WU Qi2,CAO Guang-wen1*
(1.Department of Epidemiology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433,China;2.Department of Urology, Changhai Hospital, Second Military Medical University,Shanghai 200433)
Abstract:
CD99, a cell adhesion molecule, is involved in the cell adhesion, apoptosis and tumor cell migration, infiltration, and invasion, and plays an important role in the development and progression of tumor. CD99 is abnormally expression in some tumors, which has potential value in the differential diagnosis, predication of metastasis capability, treatment and predication of tumors.
Key words:  CD99  neoplasms  gene