| 摘要: |
| 肺外成体干细胞移植治疗急性肺损伤具有巨大的应用前景。移植入体内的肺外成体干细胞首先在损伤肺组织细胞释放的一系列信号因子的引导下归巢到肺损伤和炎症部位,分化为肺组织细胞(肺上皮细胞、血管内皮细胞等)并发挥相应功能。干细胞移植后不仅具有分化能力,还具有抗炎效应和免疫调节功能,成为目前新的研究热点。 |
| 关键词: 成体干细胞 干细胞移植 急性肺损伤 生物学作用 |
| DOI：10.3724/SP.J.1008.2009.0713 |
| 投稿时间：2008-08-28修订日期：2009-05-04 |
| 基金项目:江西省教育厅青年科学基金(GJJ09432). |
|
| Ex pulmonary adult stem cell engraftment in treatment of acute lung injury: recent progress |
| ZHU Feng1,HU Zhen-zhen2,GUO Guang-hua3* |
| (1.Intensive Care Unit,The First Affiliated Hospital of Nanchang University,Nanchang 330006,China; 2.Department of Pathophysiology,Medical College of Nanchang University,Nanchang 330006;3.Burn Institute,The First Affiliated Hospital of Nanchang University,Nanchang 330006) |
| Abstract: |
| Engraftment with expulmonary adult stem cells has great potential for treatment of acute lung injury (ALI).The engrafted adult expulmonary stem cells can migrate to the injured lung tissue guided by a series of signal factors released by injured pulmonary tissue cells.Stem cells localized in the injured lung tissue and inflammatory area can differentiate into lung tissue cells (including lung epithelial cells and pulmonary vascular endothelial cells) and exert their functions.The engrafted expulmonary adult stem cells are not only capable of differentiation,but also have antiinflammatory effect and immunomodulatory effect,making the related area a focus of study. |
| Key words: adult stem cell stem cell transplantation acute lung injuries biological effect |
