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杜仲籽总苷抗炎镇痛作用研究
宋林奇1,杜先婕1,林飞2,谢人明1,孙文基1*
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(1.西北大学陕西省生物医药重点实验室,西安 710019;2.陕西中医学院,咸阳 712046)
摘要:
目的:研究杜仲籽总苷的抗炎、镇痛作用。方法:采用二甲苯所致小鼠耳肿胀和大鼠角叉菜胶足肿胀方法,研究杜仲籽总苷的抗炎作用;采用热板法、醋酸扭体法、光照甩尾法,研究杜仲籽总苷的镇痛作用。结果:杜仲籽总苷的110、220 mg/kg剂量都能明显减少二甲苯所致小鼠耳肿胀的体积,杜仲籽总苷的55、110、220 mg/kg剂量在给药后4 h左右明显减少大鼠角叉菜胶足肿胀率;杜仲籽总苷的220 mg/kg剂量能显著提高热板和光电引起小鼠的痛阈值,杜仲籽总苷的110、220 mg/kg剂量能显著地减少醋酸引起的扭体次数。结论:杜仲籽总苷具有较强的抗炎、镇痛作用。
关键词:  杜仲籽总苷  抗炎  镇痛
DOI:10.3724/SP.J.1008.2009.0413
投稿时间:2008-09-02修订日期:2009-02-19
基金项目:国家科技部支撑计划(2006BAI06A19-09) .
Anti-inflammatory and analgesic activity of Eucommiae ulmoides seed total glycoside
SONG Lin-qi1, DU Xian-jie1,LIN Fei2,XIE Ren-ming1, SUN Wen-ji1 *
(1.Key Biomedical Laboratory of Shaanxi Province, Northwest University, Xi’an 710019, China; 2.College of Traditional Chinese Medicine of Shaanxi Province, Xianyang 712046)
Abstract:
Objective:To investigate the anti-inflammatory and analgesic activity of Eucommiae ulmoides seed total glycoside(EUG). Methods: Dimethyl benzene(DB)-induced mouse ear edema model and carrageein-induced rat paw edema model were employed for the anti-inflammatory activity experiment. The experiment for analgesic activity was done using hot plate test, photoelectricity-induced test and acetic acid-induced writhing method. Results: EUG at 110,220 mg/kg showed an obvious inhibitory effect against DB-induced mouse ear edema volume, and at 55, 110, 220 mg/kg it showed an obvious analgesic effect against carrageein-induced rat paw edema rate 4 hours after oral administration. At 220 mg/kg EUG notably raised the pain threshold in the mice stimulated by hot plate and photoelectricity. At 110,220 mg/kg EUG greatly reduced the number of acid-induced writhing. Conclusion: The result suggests that EUG has potential anti-inflammatory and analgesic activity.
Key words:  Eucommiae ulmoides seed total glycoside  anti-inflammatory  analgesic