| 摘要: |
| 骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)是一种多潜能的非造血干细胞,可以向多系分化,如骨、脂肪和软骨,并优先归巢于损伤组织,有利于组织修复。体外研究显示它们不诱导免疫应答,对识别、清除同种异体抗原的免疫细胞具有抑制作用。在动物实验中,骨髓间充质干细胞可以诱导外周免疫耐受并向损伤处迁移,抑制致炎细胞因子的释放,促进损伤组织修复。这种独特作用说明它们在细胞治疗和自身免疫性疾病治疗中发挥了积极作用。 |
| 关键词: 骨髓间充质干细胞 免疫调节 免疫抑制 |
| DOI：10.3724/SP.J.1008.2009.0717 |
| 投稿时间：2008-09-23修订日期：2009-02-20 |
| 基金项目: |
|
| Immunomodulation of bone marrow mesenchymal stem cells |
| SHEN Na1,CHEN Nai-yao1*,ZHENG Li-kun2 |
| (1.Department of Hematology,Affiliated Hospital of North China Coal Medical College,Tangshan 063000,China;2.Department of Hematology,Kailuan Hospital,North China Coal Medical College,Tangshan 063000) |
| Abstract: |
| Bone marrow mesenchymal stem cells (BMSCs) are multipotent nonhematopoietic progenitor cells capable of differentiating into multiple lineages,such as bone,fat,and cartilage.BMSCs preferentially home to the damaged tissue and are beneficial to tissue repair.In vitro studies have shown that they do not induce immune response and can inhibit immune cells involved in alloantigen recognition and elimination.In animal models,BMSCs have been shown to induce peripheral tolerance and migrate to injured tissues,where they can inhibit the release of pro-inflammatory cytokines and promote the survival of damaged cells.The unique properties of MSCs suggest a role in cell therapy and treatment of immunomediated diseases. |
| Key words: bone marrow mesenchymal stem cells immunomodulation immunosuppression |
