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蛋白酶激活受体2在类风湿关节炎中的作用研究进展
刘随意△,阳青松△,贾益鑫,戴生明*
0
(第二军医大学长海医院风湿免疫科,上海 200433)
摘要:
蛋白酶激活受体2 (protease activated receptor-2,PAR-2)是G蛋白偶联受体,主要是由肥大细胞表达,并可被胰酶、类胰蛋白酶激活,然后可导致肥大细胞去颗粒化而引起炎症。类风湿关节炎发生的本质过程可能就是通过激活肥大细胞上表达的PAR-2起作用。
关键词:  蛋白酶激活受体2  类风湿关节炎  肥大细胞  类胰蛋白酶类
DOI:10.3724/SP.J.1008.2009.0725
投稿时间:2008-09-24修订日期:2009-05-06
基金项目:国家自然科学基金(30872338).
Role of protease activated receptor-2 in rheumatoid arthritis: recent progress
LIU Sui-yi△,YANG Qing-song△,JIA Yi-xin,DAI Sheng-ming*
(Department of Rheumatology & Immunology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China)
Abstract:
Protease activated receptor-2 (PAR-2) is a G-protein-coupled receptor.Recent studies indicate that PAR-2 is mainly expressed in leukocytes and activated by pancreatin and (or) tryptase,which subsequently induces inflammation through degranulation of leukocytes.Activation of PAR-2 in leukocytes is possibly involved in the pathogenesis of rheumatoid arthritis.
Key words:  protease activated receptor-2  rheumatoid arthritis  mast cells  tryptases