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电压门控性钾通道与三叉神经痛
李娜1,马蓓2*,邓小明1*
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(1.第二军医大学长海医院麻醉科,上海 200433; 2.第二军医大学基础部生理学教研室,上海 200433)
摘要:
电压门控性钾通道维持神经元静息膜电位,参与细胞兴奋性的改变。在三叉神经痛发病过程中,三叉神经节神经元作为初级感觉神经元,在痛觉的传导和传递过程中起重要作用。电压门控性钾通道的多种类型在三叉神经节神经元中均有表达,激活时产生不同类型的钾电流。电压门控性钾通道功能的改变,及其与多种神经递质、炎性介质和受体间的相互作用,在三叉神经痛的发病过程中起到了重要作用。
关键词:  电压门控钾通道  三叉神经痛  三叉神经节  背根神经节  受体
DOI:10.3724/SP.J.1008.2009.0432
投稿时间:2008-11-20修订日期:2008-12-17
基金项目:上海市科学技术委员会基金(08JC1405400).
Voltage-gated potassium channels and trigeminal neuralgia
LI Na1, MA Bei2*, DENG Xiao-ming1*
(1.Department of Anaesthiology, Changhai Hospital, Second Military Medical University, Shanghai 200433,China;2.Department of Physiology, College of Basic Medical Sciences,Second Military Medical University, Shanghai 200433)
Abstract:
Voltage-gated potassium channels regulate cell membrane potential and excitability in neurons. Trigeminal ganglion as a primary sensory neuron plays an important role in the pain transduction and transmission of trigeminal neuralgia. Trigeminal ganglion neurons express many subtypes of voltage-gated potassium channels and they can evoke different type of K+ current when activated. The alteration of voltage-gated potassium channels and their interaction with neurotransmitters, inflammatory cytokines and receptors play important roles in the development of trigeminal neuralgia.
Key words:  voltage-gated potassium channels  trigeminal neuralgia  trigeminal ganglion  dorgalroot ganglia  receptors