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鸦胆子油自乳化制剂处方研究
刘彦1,李国栋2*,刘承初1
0
(1.上海海洋大学食品学院海洋药物开发教研室,上海 201306 ;2.第二军医大学药学院药剂学教研室,上海200433)
摘要:
目的:研究鸦胆子油自乳化制剂,探求其最佳处方配比,进行剂型改进。方法:通过溶解度实验、正交筛选和伪三元相图的绘制,以乳化程度、未乳化油的体积和所得乳滴粒径的大小为指标,对鸦胆子油处方中的药物、油相、表面活性剂的用量比例进行筛选,寻找出最佳的搭配和处方配比。结果:在鸦胆子油的自乳化制剂处方中,当油相选用中链脂肪酸三酰甘油、非离子表面活性剂选用吐温-85时,可以获得较好的乳化效果,粒径为0.169 2 μm,且乳化制剂的质量、稳定性与重现性良好。结论:鸦胆子油自乳化的最佳处方比例为鸦胆子油中链脂肪酸三酰甘油吐温-85=114。
关键词:  鸦胆子油  自乳化  剂型改进
DOI:10.3724/SP.J.1008.2009.01069
投稿时间:2008-12-15修订日期:2009-07-30
基金项目:
Recipe for self-emulsifying preparation of Brucea javanica seed oil
LIU Yan1,LI Guo-dong2*,LIU Cheng-chu1
(1.Department of Ocean Drug Development,College of Food Industry,Shanghai Ocean University,Shanghai 201306,China; 2.Department of Pharmaceutics,School of Pharmacy,Second Military Medical University,Shanghai 200433)
Abstract:
Objective:To search for the optimum formula for self-emulsifying preparation of Brucea javanica seed oil.Methods: Taking the emulsifying degree,quantity of non-emulsifying oil,and emulsion particle size as parameters,we screened for the optimum proportions of the oil,lipids, and non-ionic surfactant in the recipe formulation through solubility experiment,orthogonal screen and drawing pseudo-three-phase diagram.Results: For the formulation of Brucea javanica seed oil,better emulsifying effect could be obtained using medium chain length fatty acid triglyceride as the lipids and Tween-85 as the non-ionic surfactant,with the emulsion particle diameter being 0.169 2 μm.And the self-emulsifying preparation had satisfactory quality,stability, and reproducibility.Conclusion: The optimum formula for self-emulsification of Brucea javanica seed oil is:Brucea javanica seed oil∶medium chain triglycerides∶Tween-85 being 1∶1∶4.
Key words:  brucea javanica seed oil  self-emulsifying  dosage form improving