| 摘要: |
| Netrin家族以经典的神经导向因子而闻名。但近年来一系列的研究发现在非神经组织中也有netrins广泛表达,提示netrin家族的功能并不像先前理解的那么简单。其中netrin-1在促进和抑制血管生成中可能具有的双向作用无疑是netrin家族新功能中最令人关注的。尽管netrin-1在血管生成中的确切作用还存在不少争论,仍加深了我们对神经系统与脉管系统间的密切联系的了解,也为临床心脑缺血性疾病、糖尿病引起的血管和神经病变等的治疗以及抑制肿瘤血管生成提供了新思路。本文综述了netrin-1在血管生成中的可能的双向作用及其潜在的临床意义。 |
| 关键词: 神经导向因子 netrin-1 血管生成 血管生成因子 |
| DOI：10.3724/SP.J.1008.2009.0950 |
| 投稿时间：2009-01-08修订日期：2009-03-30 |
| 基金项目: |
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| The possible dual role of neuronal guidance factor netrin-1 during angiogenesis and vascularization |
| HU Jia△,ZHU Chao△,HUANG Mao* |
| (Center of New Drug Evaluation,College of Basic Medical Sciences,Second Military Medical University,Shanghai 200433,China) |
| Abstract: |
| The netrin family is known as classical axon guidance factors.Recent studies suggested the wide existence of netrins in non-nerve tissues,indicating a more complicated role for netrin family than previously known.The dual role of netrin-1 in promoting and inhibiting vasculariztion is undoubtedly the most attractive research area.Though the specific role of netrin-1 in vascularization is not determined,it casts new lights on the close link between the nervous system and vascular system,and it also provides new thoughts on the treatment of cardiac and cerebral ischemia disorders,diabetes-induced vascular and nervous disorders,and on inhibition of tumor angiogenesis.This paper reviews the possible dual role of netrin-1 in vascularization and its potential significance. |
| Key words: neuronal guidance factor netrin-1 angiogenesis angiogenic factor |
