| 摘要: |
| 原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)是一种原因不明的自身免疫性肝病, 多伴有血脂代谢异常, 以低密度脂蛋白胆固醇增高为主要特点。大量的临床观察和前期实验研究发现PBC患者发生动脉粥样事件的危险性和病死率并未增加, 本文复习相关文献，就此现象的可能原因及潜在机制进行分析。 |
| 关键词: 原发性胆汁性肝硬化 高脂血症 动脉粥样硬化 |
| DOI：10.3724/SP.J.1008.2010.0904 |
| 投稿时间：2009-03-03修订日期：2010-04-19 |
| 基金项目: |
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| Non-elevated cardiovascular risk in patients with primary biliary cirrhosis and hypercholesterolemia |
| XIONG Yi-song,,ZHONG Ren-qian* |
| (Department of Laboratory Medicine, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China) |
| Abstract: |
| Primary biliary cirrhosis (PBC) is an autoimmune disease with unknown causes. Most PBC patients have abnormal lipid metabolism characterized by hypercholesterolemia. Paradoxically, clinical observations and pre-experimental studies showed that the risk of hyperlipidemia associated cardiovascular event and the mortality of PBC patients were not increased. In this review we summarize the possible reasons and the underlying mechanisms. |
| Key words: primary biliary cirrhosis hypercholesterolemia cardiovascular risk |
