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生长分化因子15与心血管疾病——从基础到临床
顾宇英,张代富*
0
(同济大学附属东方医院心内科,上海 200120)
摘要:
生长分化因子-15(growth differentiation factor-15, GDF-15)是转化生长因子β(transforming growth factor β,TGF-β)超家族成员的一个远支,是一个重要的心血管保护因子。作为新的标志物, GDF-15水平与多种心血管疾病的诊断、危险分层和预后判断有密切关系。本文就GDF-15基因的生物学特点及其在心血管疾病中的多种功能作一综述。
关键词:  生长分化因子15  转化生长因子β  心血管疾病
DOI:10.3724/SP.J.1008.2010.0317
投稿时间:2009-08-12修订日期:2009-11-19
基金项目:
Growth differentiation factor-15 in cardiovascular disease: from bench to bedside
GU Yu-ying, ZHANG Dai-fu*
(Department of Cardiology, East Hospital, Tongji University, Shanghai 200120, China)
Abstract:
Growth differentiation factor (GDF)-15, a distant member of the transforming growth factor-β cytokine superfamily, is a powerful cardioprotective factor. Many studies have demonstrated that serum GDF-15 level is a novel marker closely associated with the diagnosis, risk stratification, and prognosis of several cardiovascular diseases. This article mainly reviews the characteristics of GDF-15 and its multifunction in cardiovascular diseases.
Key words:  growth differentiation factor-15  transforming growth factor-β  cardiovascular diseases