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肥胖性高血压机制研究进展
罗益滨1△,朱天怡2△,陈震3,武晋晓1*,彭晓君4
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(1.北京军区总医院内分泌科,北京 100700;2.第二军医大学研究生院,上海 200433;3.北京军区总医院医务部,北京 100700;4.北京军区总医院内科学教研室,北京 100700)
摘要:
肥胖是原发性高血压的第一危险因素。肥胖性高血压发病率与日俱增,已经成为一个不容忽视的全球性问题,但其机制尚未完全阐明。本文复习了近年来的相关文献,着重从低血清脂联素、瘦素及瘦素抵抗、胰岛素及胰岛素抵抗、肾素血管紧张素系统激活4个方面阐述了肥胖性高血压的发生、发展机制。
关键词:  肥胖性高血压  脂联素  瘦素  胰岛素  肾素 血管紧张素系统
DOI:10.3724/SP.J.1008.2010.0442
投稿时间:2009-10-04修订日期:2010-01-28
基金项目:
Mechanisms of obesity related hypertension:recent progress
LUO Yi-bin1△, ZHU Tian-yi2△, CHEN Zhen3, WU Jin-xiao1*, PENG Xiao-jun4
(1. Department of Endocrinology, General Hospital, PLA Beijing Military Area Command, Beijing 100700, China;2. Postgraduate College, Second Military Medical University, Shanghai 200433, China;3. Medical Department, General Hospital, PLA Beijing Military Area Command, Beijing 100700, China;4. Department of Internal Medicine, General Hospital, PLA Beijing Military Area Command, Beijing 100700, China)
Abstract:
Obesity is the most important risk factor of primary hypertension.Rapid increase of obesityrelated hypertension has become a worldwide problem. But the specific mechanism of the condition remains to be fully understood. This paper reviews the latest literatures and tries to explain the mechanism of obesityrelated hypertension from the following four aspects:hypoadiponectinemia, leptin and resistance of leptin, insulin and resistance of insulin and the activation of reninangiotensin system(RAS).
Key words:  obesity related hypertension  adiponectin  leptin  insulin  renin angiotensin system