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| 内皮前体细胞功能与临床应用 |
| 黄亚莉1,汪燕1,陆彤2* |
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| (1. 解放军411医院干部病房科,上海 200081;2. Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA) |
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| 摘要: |
| 从骨髓释放的循环血内皮前体细胞（EPCs）具有内分泌、血管内皮修复和血管再生功能,对动脉粥样硬化的发生、发展起重要作用。然而,循环内皮前体细胞的数量和功能在心血管疾病患者中明显下降。这些细胞的数量和功能不仅受许多生理和病理因素的影响,包括衰老、糖尿病、高血压、高血脂等；也与个人的生活方式,如：运动、体质量、吸烟等心血管疾病危险因子密切相关。本文着重讨论循环血内皮前体细胞的功能及影响因素,并对其在心血管疾病中的临床应用前景作一展望。 |
| 关键词: 内皮前体细胞 心血管疾病 危险因素 治疗应用 |
| DOI：10.3724/SP.J.1008.2010.0545 |
| 投稿时间：2009-10-12修订日期：2010-04-26 |
| 基金项目: |
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| Endothelial progenitor cells: functions and clinical application in cardiac and vascular diseases |
| HUANG Ya-li1, WANG Yan1, LU Tong2* |
| (1. Cader’s Ward, No. 411 Hospital of PLA, Shanghai 200081, China;2. Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA) |
| Abstract: |
| Circulating endothelial progenitor cells (EPCs) derived from bone marrow are capable of endocrine, reendothelialization of injured blood vessels and neovascularization of ischemic lesions; besides, they also play a major role in the pathogenesis of atherosclerosis. However, the number and functions of circulating EPCs are greatly declined in patients suffering from cardiovascular diseases. Functions of EPCs are associated with not only pathophysiological factors such as aging, hypertension, diabetes and hyperlipidemia, but also personal lifestyle such as exercise, body weight and smoking, which directly influence the development of cardiovascular diseases. In this review, we mainly focus on the relationship between EPCs and cardiovascular risk factors and the potential roles of EPC therapy for cardiovascular diseases. |
| Key words: endothelial progenitor cells cardiovascular diseases risk factors therapeutic uses |
