| 摘要: |
| 已知肝星状细胞(hepatic stellate cells, HSCs)活化是肝纤维化的核心环节。越来越多的基础和临床研究证实,肝纤维化可以逆转。而肝纤维化消退的主要表现之一是活化型HSCs数量不断减少。因此,如何清除活化型HSCs并使之成为抗肝纤维化治疗新策略正逐渐受到关注。现有两种可能机制用于解释活化型HSCs的清除现象,即活化型HSCs的表型逆转和凋亡。本文旨在对基于活化型HSCs清除机制的抗肝纤维化策略进展做一综述。 |
| 关键词: 肝纤维化 肝星状细胞 表型 细胞凋亡 |
| DOI：10.3724/SP.J.1008.2010.01017 |
| 投稿时间：2009-11-03修订日期：2010-04-25 |
| 基金项目:国家科技重大专项(2008ZX10002-021). |
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| Clearance mechanisms of activated hepatic stellate cells and related antifibrotic therapies for chronic liver disease |
| LI Jing,YIN Zheng-feng* |
| (Department of Molecular Oncology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China) |
| Abstract: |
| The activation of hepatic stellate cells (HSCs) is the key step for liver fibrogenesis and progression. Increasing clinical and experimental studies suggest that hepatic fibrosis is reversible. One of the major manifestations for reduction of fibrosis is the decrease of activated HSCs. Thus, how to clear the activated hepatic stellate cells has become a focus of study on treatment of hepatic fibrosis. By now there have been two potential pathways for reduction of activated HSCs: reversal of the phenotype of HSCs and apoptosis. This paper reviews the anti-hepatic fibrosis strategies based on the clearance of activated HSCs. |
| Key words: liver fibrosis hepatic stellate cells phenotype apoptosis |
