| 摘要: |
| 目的研究盐酸布比卡因的电化学行为,建立盐酸布比卡因电化学检测方法。方法采用循环伏安(CV)进行盐酸布比卡的电化学性质的研究,差分脉冲 (DPV)法进行盐酸布比卡因的含量检测。结果在0.01 mol/L高氯酸四丁基铵缓冲溶液(TBAP)中,盐酸布比卡因的微量水溶液在铂电极上的氧化峰电流与其浓度在1×10-5～2×10-4mol/L 的范围内呈良好的线性关系,线性回归相关系数为 0.995 8,检出限为1.0×10-5mol/L。结论该方法准确可靠,操作简便、快速,重现性好,可应用于盐酸布比卡因原料药的检测。 |
| 关键词: 布比卡因 电化学 |
| DOI：10.3724/SP.J.1008.2010.0794 |
| 投稿时间：2009-11-09修订日期：2010-05-09 |
| 基金项目: |
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| Electrochemical method in determination of bupivacaine hydrochloride content in bupivacaine bydrochloride raw medicine |
| LI Duan*, PAN Guo-shi, ZHANG Ye, WU Jian,吴剑 |
| (School of Pharmacy, Anhui College of Traditional Chinese Medicine, Wuhu 241000, Anhui, China;Anhui College of Chinese Traditional Medicine) |
| Abstract: |
| ObjectiveTo study the electrochemical behavior of bupivacaine hydrochloride and to establish an electrochemical method for determination of bupivacaine hydrochloride.MethodsThe electrochemical behavior of bupivacaine hydrochloride was studied by cyclic voltammetry (CV), and differential pulse voltammetry (DPV) was used to determine the contents of bupivacaine hydrochloride.ResultsIn a 0.01 mol/L tetrabutylammonium perchlorate (TBAP) buffer solution, the oxidization peak current on the platinum electrode in the bupivacaine hydrochloride solution was in a good linear relation over a concentration range of 1.0×10-5-2.0×10-4 mol/L, with the r value being 0.995 8, and a detection limit of 1×10-5 mol/L (by DPV).ConclusionOur method is accurate, easy to perform, and with good repeatability, and it can be used to determine bupivacaine hydrochloride content in bupivacaine hydrochloride raw medicine. |
| Key words: bupivacaine electrochemistry analysis |
