| 摘要: |
| 丙型肝炎病毒(hepatitis C virus，HCV)的细胞入侵过程由多因素介导，包括多种受体及触发病毒内吞入胞的细胞因素。新发现的受体分子occludin已被证明与SR-B1、CD81、claudin同介导HCV细胞入侵,occludin和claudin同为组成细胞间紧密连接的整合蛋白，引起了研究者们对紧密连接及细胞极性对HCV入侵影响的广泛关注。对细胞极性及紧密连接的研究，有助于发现新的HCV治疗药物的作用靶点，从而干预其细胞入侵及细胞间蔓延。本文从肝细胞极性特点、紧密连接及主要整合蛋白claudin和occludin、极性细胞模型及与HCV入侵的关系等几个方面综述了近来的最新进展。 |
| 关键词: 丙型肝炎病毒 细胞极性 紧密连接 细胞入侵 occludin |
| DOI：10.3724/SP.J.1008.2010.0892 |
| 投稿时间：2009-12-22修订日期：2010-05-28 |
| 基金项目:国家传染病重大专项课题(2008ZX10002-013),上海市基础研究重点项目(08JC1405000),上海市重点学科建设项目(B901). |
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| Cell polarization and hepatitis C virus receptor-mediated cell entry |
| GUAN Mo,,QI Zhong-tian |
| (Department of Microbiology, Shanghai Key Laboratory of Medical Biodefense, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China) |
| Abstract: |
| Hepatitis C virus cell entry is mediated by multiple factors, including various receptors and cellular factors that trigger virus uptake by the hepatocyte. Occludin is a newly identified essential co-receptor for HCV entry together with CD81, SR-B1 and CLDN1. CLDN1 and occludin highlight the importance of studying the effects of tight junction and cell polarization on HCV entry. Study on cell polarization and tight junction can help to discover new targets for HCV therapy, and therefore interfere the cell entry and cell-cell spread of HCV. This review summarizes the current knowledge of hepatocyte polarization, tight junction and its major integral proteins CLDN1 and occludin, polarized cell culture system and its relation with HCV entry.
\[Key words\] hepatitis C virus; cell polarization; tight junction; cell entry; occludin |
| Key words: hepatitis C virus cell polarization tight junction cell entry occludin |
