| 摘要: |
| GATA3转录因子在正常乳腺的生长分化中起重要作用,与乳腺癌的发生发展也密切相关,GATA3在不同乳腺癌亚型发生中的作用有所不同。本文综述了GATA3与正常乳腺及乳腺癌发生发展关系的研究现状,为今后研究GATA3在乳腺癌中的临床应用提供理论依据。 |
| 关键词: GATA3转录因子 乳腺肿瘤 乳腺 |
| DOI：10.3724/SP.J.1008.2010.0787 |
| 投稿时间：2010-03-10修订日期：2010-05-31 |
| 基金项目: |
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| Relationship of GATA3 with development and progression of breast cancer |
| XIE Yi-qun1,2, SHI Jun-yi1*, LI Xi-zhou1, SUI Jin-ke1,SHI Jun-yi |
| (1.Department of General Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2.Department of Breast Surgery, Shanghai Huangpu Center Hospital, Shanghai 200002, China) |
| Abstract: |
| GATA3 transcription factor plays an important role in the growth and differentiation of normal breast tissues, and it is also closely related to the tumorigenesis of breast cancer.The roles of GATA3 vary in different breast cancer subtypes.This paper reviews the relationship of GATA3 with normal breast tissue and the tumorigenesis of breast cancer, in an attempt to provide theoretical evidences for future clinical applications of GATA3 in breast cancer. |
| Key words: GATA3 transcription factor breast neoplasms breast |
