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中药射干的化学成分分析
冯传卫,沈刚,陈海生
0
(第二军医大学药学院天然药物化学教研室,上海 200433)
摘要:
目的对中药射干Belamcanda chinensis(L.)DC根茎80%乙醇提取物进行化学成分分析。方法利用硅胶色谱、Sephadex LH-20色谱以及反相HPLC等手段进行分离纯化,应用MS、NMR等光谱方法对分得的化合物进行结构鉴定。结果从射干根茎中分离并鉴定了10个化合物,分别为鸢尾苷(tectoridin,Ⅰ),香草乙酮(acetovanillone,Ⅱ),对羟基苯乙酮(4-hydroxy-acetophenone,Ⅲ),β-谷甾醇(β-sitosterol,Ⅳ),β-胡萝卜苷(β-daucosterol,Ⅴ),5,7,4′-三羟基-3′,5′-二甲氧基黄酮(5,7, 4′-trihydroxyl-3′,5′-dimethoxyflavone,Ⅵ),木犀草素(luteolin,Ⅶ),芹菜素(apigenin,Ⅷ),5,7,4′-三羟基二氢黄酮(5,7,4′-trihydroxyflavanones,Ⅸ),异鼠李素(isorhamnetin,Ⅹ)。结论化合物Ⅵ、Ⅶ、Ⅷ、Ⅸ为首次从射干中分离得到。
关键词:    化学成分  黄酮类
DOI:10.3724/SP.J.1008.2010.01120
投稿时间:2010-03-12修订日期:2010-07-28
基金项目:上海市科委登山计划 (7dZ19721-2), 上海市重点实验室建设资助(B906).
Studies on chemical constituents of Belamcanda chinensis
FENG Chuan-wei, SHEN Gang, Chen hai-sheng
(Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China)
Abstract:
ObjectiveTo investigate the chemical constituents of 80% ETOH extract from rhizome of Belamcanda chinensis (L.) DC. MethodsThe constituents were isolated and purified by chromatography on silica gel, Sephadex LH-20 and HPLC; the structures of the compounds were determined by MS and NMR spectral analysis. ResultsTen constituents were identified from rhizome of Belamcanda chinensis (L.) DC, including tectoridin (Ⅰ), acetovanillone (Ⅱ), 4-hydroxy-acetophenone (Ⅲ), β-sitosterol (Ⅳ), β-daucosterol(Ⅴ), 5,7,4′-trihydroxyl-3′,5′-dimethoxyflavone (Ⅵ), luteolin (Ⅶ), apigenin (Ⅷ), 5,7,4′-trihydroxyflavanones (Ⅸ), and isorhamnetin (Ⅹ).ConclusionCompounds Ⅵ, Ⅶ, Ⅷ, and Ⅸ have been isolated from rhizome of Belamcanda chinensis for the first time.
Key words:  Belamcanda chinensis  chemical constituents  flavones