| 摘要: |
| 目的测定卵巢上皮性癌患者血清中HER-2/neu自身抗体的表达水平,探讨其作为卵巢上皮性癌血清学标志物的诊断价值。方法采用ELISA法检测2007年至2009年40例卵巢上皮性癌患者、20例良性上皮性卵巢肿瘤患者和20例正常对照女性的血清HER-2/neu自身抗体水平；采用统计学方法分析血清HER-2/neu自身抗体的诊断价值。结果卵巢上皮性癌患者血清HER-2/neu自身抗体水平显著高于良性上皮性卵巢肿瘤患者和正常女性(P<0.05)。ROC曲线分析显示HER-2/neu自身抗体用于卵巢上皮性癌诊断的灵敏度和特异性分别为47.5%和97.5%；联合CA125检测可提高诊断特异性至90%且不降低灵敏度。偏相关系数表明血清CA125与HER-2/neu自身抗体水平无相关性。结论血清HER-2/neu自身抗体水平与卵巢上皮性癌相关,有望成为卵巢上皮性癌诊断的一种新血清学标志物。 |
| 关键词: 卵巢上皮性癌 HER-2/neu 自身抗体 CA125 |
| DOI：10.3724/SP.J.1008.2010.01076 |
| 投稿时间：2010-04-08修订日期：2010-08-27 |
| 基金项目: |
|
| Serum HER-2/neu autoantibody in patients with epithelial ovarian cancer and its diagnostic value |
| Hui Ning,WU Dong, WANG Meng, HUI Ning* |
| (Department of Obstetrics and Gynecology, Changhai Hospital, Second Military Medical University, Shanghai 200433,China) |
| Abstract: |
| ObjectiveTo determine the serum HER-2/neu autoantibody level in patients with epithelial ovarian cancer and to evaluate the potential of using HER-2/neuautoantibody as a tumor marker. MethodsThe serum HER-2/neu autoantibody levels were measured by ELISA in 20 normal controls, 20 patients with benign epithelial ovarian tumors and 40 patients with epithelial ovarian cancer during 2007 to 2009. Statistical analysis was performed to determine the diagnostic value of serum HER-2/neu autoantibody. ResultsThe sera of epithelial ovarian cancer patients expressed higher levels of HER-2/neu autoantibody than those of benign epithelial ovarian tumor patients and normal controls (P<0.05). The ROC curve results showed that the HER-2/neu autoantibody screening exhibited a sensitivity of 47.5% and a specificity of 97.5% for diagnosis of epithelial ovarian cancer. Compared with serum CA125 measurement, the combined measurement of CA125 and HER-2/neu autoantibody yielded an increased specificity of 90% without decreasing the sensitivity. And no association was found for serum CA125 and HER-2/neu autoantibody using partial correlation coefficient. ConclusionIt is shown that the serum HER-2/neu autoantibody level is associated with epithelial ovarian cancer and can serve as a potential serological biomarker for epithelial ovarian cancer diagnosis. |
| Key words: epithelial ovarian cancer HER-2/neu autoantibody CA125 |
