| 摘要: |
| \[摘要\]随着社会经济、科技的发展，纳米材料在各个领域中的应用也越来越广泛，在给人们生活带来便利的同时，纳米材料的毒性效应也日益受到人们的高度关注。本文就纳米材料的特殊物理化学特性、纳米材料细胞生物毒性的研究方法、纳米材料对细胞造成的毒性效应等方面，综合阐述几种纳米材料（碳基纳米材料、金属及金属氧化物等）的细胞毒性效应及存在的问题。最后，展望了该研究方向的研究重点和亟待研究的重要问题，为研究纳米材料的生物安全性提供导向。 |
| 关键词: 纳米材料 细胞毒性效应 生物安全性 |
| DOI：10.3724/SP.J.1008.2010.01234 |
| 投稿时间：2010-04-19修订日期：2010-08-11 |
| 基金项目:国家重点基础研究发展计划 (2006CB932505), 上海市科学技术委员会纳米专项 (0752nm020). |
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| Study on cytotoxic effects of several types of nano-materials: the current status |
| ZHANG Yan-fang1，2, JIN Chan2, MA Chun-wang1, YANG Yong-ji2* |
| (1. Institute of Theoretical Physics, College of Physics and Information Engineering, Henan Normal University, Xinxiang 453007, Hennan, China; 2. Institute of Biophysics, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China) |
| Abstract: |
| \[Abstract\]Nano-materials have been increasingly widely used in various fields with the progression in science and technology. While bringing benefit to our life, their toxic effects also come to our attention. In this paper we review the cytotoxic effects and some problems of several kinds of nano-materials (carbon-based nano-materials, metal and metallic oxides and other nano-materials), considering the physicochemical characteristics of nano-materials, research methods of the nano-material cytotoxic effects, and the cytotoxcity of nano-materials. Finally, we also discuss the research focus of the area and issues need to be addressed, hoping to provide a guide for bio-safety research of nano-materials. |
| Key words: nano-materials cytotoxicity effect bio-safety |
