| 摘要: |
| 他汀类药物是一类降血脂药,它们是羟甲基戊二酸单酰辅酶A还原酶的抑制剂。他汀类药物具有多效性,最近的研究表明其可能具有防治帕金森病的潜力。本文就近年来他汀类药物在防治帕金森病的临床效果及作用机制方面的研究进展作一综述。 |
| 关键词: 他汀类药物 帕金森病 预防 治疗 |
| DOI：10.3724/SP.J.1008.2011.092 |
| 投稿时间：2010-05-06修订日期：2010-10-29 |
| 基金项目: |
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| Efficacy and mechanism of statins in prevention and treatment of Parkinson disease: recent progress |
| QI Min1△,WEI Xian-zhao2△,JIANG Xiu-feng3* |
| (1. Changzheng Clinical Medical College, Second Military Medical University, Shanghai 200003, China;;2. Changhai Clinical Medical College, Second Military Medical University, Shanghai 200433, China;;3. Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China) |
| Abstract: |
| Statins are a class of hypolipidemic drugs, and they are HMGCoA reductase inhibitors. Statins are pleiotropic; recent studies have suggested that they might have a potential for prevention and treatment of Parkinson disease. This paper reviews recent researches about the roles of statins in the prevention and therapy of Parkinson disease in the nearest few years. |
| Key words: statins Parkinson disease prevention therapy |
