【打印本页】 【下载PDF全文】 【HTML】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 1815次   下载 1840 本文二维码信息
码上扫一扫!
p73基因及其在妇科肿瘤中的研究进展
彭平平,黄利鸣*,王艳林
0
(三峡大学医学院分子生物学研究所,宜昌 443002)
摘要:
p73作为p53家族成员之一,因具有与p53极为类似的结构和功能受到广泛关注。其中p73基因全长模式TAp73能够引起细胞周期停滞和诱导细胞凋亡,并能作用于p53的靶基因,推测TAp73很可能是另一个新型的抑癌基因。该基因的深入研究将为癌症的诊断和治疗提供新视野。本文将对p73的结构、生物学功能及其与妇科肿瘤发生、发展、预后之间的关系简要阐述。
关键词:  p73  肿瘤抑制基因  细胞凋亡  女性生殖器肿瘤  乳腺肿瘤
DOI:10.3724/SP.J.1008.2011.0334
投稿时间:2010-07-11修订日期:2010-12-24
基金项目:国家自然科学基金(30873282), 湖北省自然科学基金(2009CDA060).
p73 gene and its role in gynecological tumors: an advance
PENG Ping-ping, HUANG Li-ming*, WANG Yan-lin
(Institute of Molecular Biology, Medical College, Three Gorges University, Yichang 443002, Hubei, China)
Abstract:
As a member of p53 family, p73 is gaining increasing attention because it has high structural and functional homology with p53. TAp73, a full-length isoform of p73, can arrest cell cycle and induce cell apoptosis; it may also exert its effect on the target gene of p53, and is therefore considered as a new tumor suppressor gene. Further research on p73 may cast new lights on the diagnosis and therapy of cancer. This paper describes the structure and function of p73 and its relationship with development, progression and prognosis of gynecological tumors.
Key words:  p73  tumor suppressor genes  apoptosis  female genital neoplasms  breast neoplasms