| 摘要: |
| 目的比较在绝经后女性骨质疏松症患者中碳酸钙D3片和维生素E联合应用与碳酸钙D3片单用的疗效。 方法筛选门诊145名51~70岁绝经后患骨质疏松症的女性患者,随机分为联合用药组与单用组,联合用药组74例,单用组71例。联合用药组服用碳酸钙D3片(每片含钙600 mg、维生素D 125国际单位,1片/次,1次/d)和维生素E(每片含维生素E 50 mg,1片/次,3次/d),单用组仅同法服用碳酸钙D3片。两组均服药1年,比较两组治疗前后的临床症状缓解情况、血清骨钙素、骨密度、雌二醇与血清碱性磷酸酶的变化情况。结果联合用药组的临床症状缓解、血清骨钙素与骨密度、雌二醇、血清碱性磷酸酶的变化情况均较单用组显著,两组比较差异有统计学意义(P<0.05)。结论联合应用碳酸钙D3片和维生素E比单用碳酸钙D3片在治疗绝经后女性骨质疏松症的效果更好。 |
| 关键词: 绝经后骨质疏松 碳酸钙 维生素E 骨密度 血清骨钙素 血清碱性磷酸酶 雌二醇 |
| DOI：10.3724/SP.J.1008.2011.0342 |
| 投稿时间：2010-07-30修订日期：2011-01-13 |
| 基金项目: |
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| Calcium carbonate D3 tablet alone or in combination with vitamin E for treatment of osteoporosis in postmenopausal women: a comparison of clinical effectiveness |
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| Abstract: |
| Abstract: Objective To compare the effect between the postmenopausal women with osteoporosis who take both vitamin E and calcium carbonate D3 tablets and take calcium carbonate D3 tablets only. Methods Select 145 postmenopausal women with osteoporosis who are aged from 51 to 70. Devide these women randomly into the test group (the group of take both vitamin E and calcium carbonate D3 tablets and the control group ，the group of take calcium carbonate D3 tablets only. Women in the test group is 74. Women in the control group is 71. Women in the test group take a pill of Carbonate D3 tablets and a pill of vitamin E everyday; while women in the control group take a pill of calcium carbonate D3 tablets everyday. The two group women are all requied to take drags for one year . Then compare the situation of the clinical symptoms ，the changes of bone gla-protein（BGP），the bone mineral density (BMD)，the estradiol and the serum alkaline phosphatase （AKP）of the women between the two group . Results The improvement of the clinical symptoms 、 the bone mineral density (BMD)，bone glo-protein（BGP），estradiol，alkaline phosphatase （AKP） in the test group is better than the control group (P<0.05). Conclusion The curative effect of the conbine-using Vitamin E and calcium carbonate D3 tablets in postmenopausal women with Osteoporosis is better than using calcium carbonate D3 tablets only. |
| Key words: Osteoporosis calcium carbonate D3 tablets Vitamin E BMD BGP estradiol AKP |
