| 摘要: |
| \[摘要\]目的探讨纤溶酶原激活因子\[组织型纤溶酶原激活因子(t-PA)、尿激酶型纤溶酶原激活因子(u-PA)\]及其抑制因子1(PAI-1)与多囊卵巢综合征(PCOS)发病机制之间的关联。方法选择2007年12月至2008年10月于中南大学湘雅三医院接受宫腹腔镜检查及手术的PCOS患者共30例及正常卵巢活检标本20例,用化学发光法检测血清性激素水平,免疫组化方法检测t-PA、u-PA及PAI-1的表达。结果PCOS组u-PA、t-PA在颗粒细胞中表达阳性率分别为20.00%及26.67%,在卵泡膜细胞中表达阳性率分别为33.33%及20.00%,对照组u-PA、t-PA在颗粒细胞中表达阳性率分别为65.00%及75.00%,在卵泡膜细胞中表达阳性率分别为75.00%及50.00%,两组比较差异有统计学意义(P<0.05)。PCOS组PAI-1在卵泡膜细胞中表达阳性率为56.67%,在间质细胞中表达阳性率为63.33%,对照组PAI-1在卵泡膜细胞中表达阳性率为10.00%,在间质细胞中表达阳性率为10.00%,两组比较差异有统计学意义(P<0.01)。结论PCOS患者卵巢组织中纤溶酶原激活、抑制因子的异常表达与PCOS排卵障碍的发生密切相关。 |
| 关键词: 多囊卵巢综合征 纤溶酶原激活物 纤溶酶原激活因子抑制因子1 卵巢 |
| DOI：10.3724/SP.J.1008.2010.01309 |
| 投稿时间：2010-09-14修订日期：2010-11-29 |
| 基金项目: |
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| Expression of plasminogen activator and plasminogen activator inhibitor in ovarian of patients with polycystic ovary syndrome |
| SHEN Jing-xin, PAN Qiong, XUE Min* |
| (Department of Gynecology, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China) |
| Abstract: |
| \[Abstract\]ObjectiveTo investigate the association of polycystic ovary syndrome (PCOS) with plasminogen activator (tissue-type plasminogen activator \[t-PA\], urokinase-type plasminogen activator \[u-PA\]) and plasminogen activator inhibitor-1 (PAI-1). MethodsThe ovary tissues of 30 PCOS patients who were treated in our hospital from Dec. 2007 to Oct. 2008 and 20 healthy controls were collected. The expression of t-PA, u-PA, and PAI-1 was examined by immunohistochemistry method. ResultsIn PCOS group, the positive rates of u-PA, t-PA in the granulosa cells were 20.00% and 26.67%, and in the theca cells were 33.33% and 20.00%, respectively; in the control group, the positive rates of u-PA, t-PA in the granulosa cells were 65.00% and 75.00%, in the theca cells were 75.00% and 50.00%, respectively; and there were significant differences between the two groups (P<0.05). In PCOS group, the positive rate of PAI-1 was 56.67% in the theca cells and 63.33% in interstitial cells; in the control group, the positive rates of PAI-1 were 10.00% both in the theca cells and the interstitial cells; and there were significant differences between the two groups (P<0.05). ConclusionThe disruption of plasminogen activator system may be involved in ovulation disorder of PCOS. |
| Key words: polycystic ovary syndrome plasminogen activator plasminogen activator inhibitor 1 ovary |
