| 摘要: |
| 目的探讨单纯性肥胖患者血管形成素相关生长因子(AGF)表达水平及其与体质指数(BMI)、腰围(WC)、腰臀比(WHR)、空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMAIR)等的关系。方法采用ELISA法检测40例正常人和40例单纯性肥胖患者血浆AGF水平,并分析了AGF水平与BMI、WC、WHR、血脂、糖化血红蛋白(HbA1c)、FBG、FINS和HOMAIR等的关系。结果单纯性肥胖患者AGF水平高于对照组[(177.55±74.09) ng/ml vs (122.37±66.91) ng/ml,P<0.05]; 线性相关分析表明,AGF水平与三酰甘油(TG)、FINS和HOMAIR呈正相关(r=0.325,P<0.05; r=0.451,P<0.01; r=0.483,P<0.01),与HDL呈负相关(r=-0.529,P<0.01)。 以AGF为因变量,性别、年龄、WC、WHR、BMI、TG、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇（LDL）、HbA1c、FBG、FINS和HOMAIR为自变量,进行多元线性逐步回归分析,结果表明HDL、BMI 和FINS是影响AGF水平的相关因素。二项Logistic回归分析表明,控制性别、年龄、TC、TG、HDL、LDL后AGF水平与单纯性肥胖仍呈显著相关(OR>1)。结论AGF水平的改变与肥胖患者的代谢紊乱有关,并可能参与了单纯性肥胖的发生和发展。 |
| 关键词: 肥胖症 血管生成素相关生长因子； 胰岛素抵抗 |
| DOI：10.3724/SP.J.1008.2011.037 |
| 投稿时间：2010-10-28修订日期：2010-12-14 |
| 基金项目: |
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| Expression of angiopoietin-related growth factor in obese patients and its significance |
| SHI Jian-xia,ZOU Da-jin* |
| (Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China) |
| Abstract: |
| ObjectiveTo investigate the expression of angiopoietinrelated growth factor (AGF) in obese patients and its relationship with body mass index(BMI), waist circumference(WC), waisthip ratio(WHR), blood glucose(FBG), plasma insulin(FINS) levels,and HOMAinsulin resistance index(HOMAIR). MethodsPlasma AGF levels were assayed by ELISA in 40 patients with obesity and 40 normal controls. The relationship of AGF level with BMI, WC, WHR, HbA1c, blood lipids, FBG, FINS, and HOMAIR was also analyzed. ResultsAGF levels in patients with obesity were significantly increased compared with that in the control group ([177.55±74.09] ng/ml vs [122.37±66.91] ng/ml,P<0.05). We also found that AGF level was positively correlated with Triglyceride(TG), FINS and HOMAIR(r=0.325, P<0.05; r=0.451, P<0.01; r=0.483, P<0.01); and was negatively correlated with highdensity lipoprotein cholesterol(HDL, r=-0.529, P<0.01). Multiple regression analysis showed that HDL, BMI and FINS were the factors influencing AGF levels. Binomial Logistic regression analysis indicated that AGF level was positively correlated with obesity after adjusting sex, age, total cholesterol(TC), TG, HDL and lowdensity lipoprotein cholesterol (LDL) (OR>1). Conclusion The change of AGF level is associated with the metabolism disorder in obese patients, and it may also contribute to the pathogenesis of obesity. |
| Key words: obesity angiopoietin-related growth factor insulin resistance |
