摘要: |
脱髓鞘病变可阻碍神经系统电传导,导致功能障碍。髓鞘再生由广泛分布于成体的少突胶质前体细胞(OPC)介导。理解少突胶质细胞生理学,了解髓鞘形成与维稳机制,了解在某些主要神经系统病变(如多发性硬化)CNS髓鞘再生失败与内源性OPC数量、迁移以及形成髓鞘能力的关系,对于改善髓鞘修复策略具有重要意义。 |
关键词: 少突胶质前体细胞 髓鞘形成 髓鞘再生 脱髓鞘 多发性硬化 |
DOI:10.3724/SP.J.1008.2011.0786 |
投稿时间:2010-12-10修订日期:2011-01-25 |
基金项目:国家重点基础研究规划("973"计划) |
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Role of oligodendrocyte precursor cells in myelination and remyelination: recent advance |
LIN Xiao-jing1,ZHAO Ting-bao2,LIU Shao-jun1 |
(1. Department of Neurobiology, Institute of Basic Medical Sciences, the Academy of Military Medical Sciences, Beijing 100850,China;2. Department of Spinal Cord Injury, General Hospital, PLA Ji’nan Military Area Command, Ji’nan 250031, Shandong, China) |
Abstract: |
Demyelination disables saltatory conduction and leads to loss of neural functions. Remyelination is mediated by oligodendrocyte precursor cells (OPCs), which are widely distributed throughout the adult CNS. A better understanding of oligodendrocyte biology, myelination, and maintenance of myelin sheaths, and the failure of remyelination in the CNS, which has been associated with the limited availability, migratory capacity and myelinating ability of endogenous OPCs, is necessary to improve remyelination strategies in a chronic inflammatory demyelinating disease such as multiple sclerosis (MS). |
Key words: oligodendrocyte precursor cells (OPC) myelination remyelination demyelination multiple sclerosis (MS) |