| 摘要: |
| 脂类组学是一门新兴的代谢组学的分支学科,旨在系统研究生物体内所有脂类分子的特性,以及它们在蛋白质表达和基因表达调节过程中的作用。脂类参与调节生物体的众多生理过程,包括能量存储、信号转导、细胞凋亡等,随着新的分析技术的发展,特别是质谱技术的应用和发展,脂类的测定得以快速、精确和高通量地进行。大量研究表明,脂类代谢异常与肿瘤的发生发展有着密切联系,脂类组学技术的应用能揭示与肿瘤相关的脂类变化,找到其异常的代谢通路,并在肿瘤脂类生物标志物的识别、肿瘤早期诊断和抗肿瘤药物靶点的发现等方面展现出广泛的应用前景。本文就上述研究的近期进展作简要综述。 |
| 关键词: 脂类 脂类组学 质谱分析法 肿瘤 |
| DOI：10.3724/SP.J.1008.2012.00663 |
| 投稿时间：2011-04-10修订日期：2011-11-29 |
| 基金项目:国家自然科学基金(81072061). |
|
| Research progress in tumor-associated lipids and lipidomics |
| FAN Zuo-xu,MA Xiao-qiong,ZHAN Ren-ya* |
(Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China
*Corresponding author.) |
| Abstract: |
| Lipidomics, a newly emerged branch of metabolomics, is aimed to systemically study the characters of lipid molecular species in organisms and their roles in regulating protein and gene expression. Lipids play diverse biological roles in organisms, including energy storage, signal transduction and apoptosis. Owning to the rapid progression of novel analytical technique, especially the application of mass spectrometry, lipid examination can be done rapidly and accurately in a high throughput manner. Many studies have demonstrated that abnormal metabolism of lipids is closely related to the development and progression of tumors. Application of lipidomics technique can reveal the changes of tumor-associated lipid and identify the abnormal metabolic pathways. Also, lipidomics has a promising future in recognition of lipid-based tumor markers, early diagnosis of tumors and the discovery of antineoplastic drug targets. In this article, we reviewed the recent progress in the above-mentioned areas. |
| Key words: lipids lipidomics mass spectrometry neoplasms |
