| 摘要: |
| 上皮间质转化(epithelial-mesenchymal transition,EMT)的主要特征是上皮表型的缺失及间质特性的获得。EMT在胚胎发育、创伤愈合及组织重建等生理过程中发挥重要作用,也参与组织纤维化及恶性肿瘤发生发展等病理过程。EMT在促使肿瘤细胞侵袭并转移至远端组织的同时,也使得转移的肿瘤细胞具有自我更新能力等干细胞样特性,有助于形成肿瘤宏观转移灶并产生多重耐药性。多种转录因子、信号转导通路、microRNAs及细胞微环境等参与并调控此过程。阐明EMT与肿瘤干细胞(cancer stem cells,CSCs)在肿瘤转移中的作用机制,将为肿瘤转移与复发的靶向治疗提供新思路。 |
| 关键词: 肿瘤 上皮间质转化 肿瘤干细胞 肿瘤转移 |
| DOI：10.3724/SP.J.1008.2011.01357 |
| 投稿时间：2011-05-13修订日期：2011-10-10 |
| 基金项目:第二军医大学创新能力培养计划基金(MS2010099). |
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| Epithelial-mesenchymal transition and cancer stem cells in tumor metastasis |
| YIN Fan, XU Xia, ZHAO, Dong-bao* |
(Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| The epithelial-mesenchymal transition (EMT) is characterized by absence of epithelial phenotype and acquiring of mesenchymal properties. EMT participates not only in normal embryonic development,wound healing and tissue reconstruction,but also in various pathologic processes,including fibrosis and carcinogenesis. EMT can facilitate the invasion and metastasis of cancer cells to distant tissues,and confer the metastatic cancer cells self-renewal ability of stem cells,contributing to macroscopical metastasis formation and multiple resistance to treatment. Recent studies have revealed that several transcription factors,signaling pathways,microRNAs and microenvironment components are involved in this process. Here we summarize the recent progress on the roles of EMT and cancer stem cells in tumor metastasis,hoping to provide new insights in target therapy of tumor metastasis and recurrence. |
| Key words: neoplasms epithelial-mesenchymal transitions cancer stem cells metastasis |
