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星形胶质细胞升高基因1在肿瘤中的多重调节功能研究进展
顾文文1,曹永兵2,姜远英2*,龚晓健1*
0
(1. 中国药科大学药学院药理学教
2. 第二军医大学药学院新药研究中心,上海 200433研室,南京 210009
*通信作者)
摘要:
星形胶质细胞升高基因1(astrocyte elevated gene 1, AEG-1)作为重要的癌基因之一,目前已被证实在多种肿瘤的发生发展过程中发挥关键性作用。近十年来研究表明AEG-1在神经母细胞瘤、黑素瘤、肝癌、乳腺癌、前列腺癌等几乎所有器官的恶性肿瘤中均有不同程度过表达,在肿瘤细胞增殖、促进血管生成、肿瘤转化、侵袭和转移以及化疗耐药等方面发挥多重调节作用,其机制涉及到PI3K/Akt、NF-κB等多个信号通路。本文主要综述近年来AEG-1在肿瘤发生发展过程中多重调节作用的相关研究进展,以及将其作为恶性肿瘤治疗新靶点的应用前景。
关键词:  星形胶质细胞升高基因1  血管生成  肿瘤转移  化疗耐药
DOI:10.3724/SP.J.1008.2012.00668
投稿时间:2011-10-15修订日期:2011-12-06
基金项目:
Astrocyte elevated gene 1 as a multifunctional regulator in cancer progression
GU Wen-wen1,CAO Yong-bing2,JIANG yuan-ying2*,GONG Xiao-jian1*
(1. Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China
2. R & D Center of New Drug, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
*Corresponding authors.)
Abstract:
Astrocyte elevated gene 1 (AEG-1), an important oncogene, has been confirmed to play a crucial role in progression (invasion, metastasis, angiogenesis and chemoresistance, etc) of multiple cancers. Over the past decade, studies have shown that AEG-1 is overexpressed in cancers involving almost all organs, including neuroblastoma, melanoma, HCC, breast, prostate cancer, etc. Moreover, AEG-1 is associated with multiple pathways including PI3K/Akt and nuclear factor-κB (NF-κB). This review mainly outlines the multiple regulating role of AEG-1 in the development and progression of tumor and to discuss its role as a novel target for treatment of malignant tumors.
Key words:  astrocyte elevated gene 1  angiogenesis  neoplasm metastasis  drug resistance