| 摘要: |
| 目的观察强化控制血糖、血压、血脂对2型糖尿病患者肥胖抑制素水平的影响及其与脂代谢的相关性。方法将72例2型糖尿病患者根据治疗方法不同分为4组: A组25例,强化血糖、血压控制; B组12例,A组基础上加用强化血脂治疗; C组20例和D组15例,在B组基础上分别加用维生素E和复方丹参滴丸治疗。结果A组空腹血浆肥胖抑制素水平低于其他3组,差异有统计学意义(P<0.01); 空腹血浆肥胖抑制素浓度与体质量指数(BMI)、腰臀比(WHR)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素(FIN)和胰岛素抵抗指数(HOMA-IR)呈负相关(P均<0.05)，与HDL-C呈正相关(P<0.05)；逐步校正年龄、性别、BMI、WHR、血糖和血压后，较高水平的空腹血浆肥胖抑制素浓度与强化控制血脂相关(P<0.01)。结论强化控制血脂较未强化控制血脂的2型糖尿病患者空腹血浆肥胖抑制素水平升高,肥胖抑制素可能与脂代谢相关。 |
| 关键词: 2型糖尿病 肥胖抑制素 强化控制血脂；脂代谢 |
| DOI：10.3724/SP.J.1008.2012.00978 |
| 投稿时间：2012-03-09修订日期：2012-05-03 |
| 基金项目:国家科技部“十五”攻关课题(2004BA702B01). |
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| Strengthening control of blood glucose, blood pressure, and blood lipids in type 2 diabetes mellitus patients: influence on obestatin level and relation with lipid metabolism |
| NI Ting-ting,ZOU Da-jin*,HUANG Qin,WANG Qi-jin,DING Chang-hua,FENG Zheng-kang |
(Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| ObjectiveTo observe the influence of intensive control of blood glucose, blood pressure and blood lipid on fasting plasma obestatin level in type 2 diabetes mellitus (T2DM) patients and its correlation with lipid metabolism. MethodsSeventy-two T2DM patients were assigned to four groups according to different treatments. Group A(n=25) received blood glucose (BG) and blood pressure(BP)controlling; group B(n=12) received BG, BP and blood lipid (BL) controlling; group C(n=20) received BG,BP, and BL controlling plus vitamin E administration; and group D(n=15) received BG,BP,BL controlling and compound Danshen dripping pill administration. ResultsFasting obestatin level of group A was significantly lower than those in the other three groups (P<0.01). Fasting obestatin level was negatively correlated with body mass index (BMI), HbAlc, waist to hip ratio (WHR)，total cholesterol(TC), low-density lipoprotein cholesterol (LDL-C), fasting insulin (FIN) and hemeostasis model assessment of insulin resistance (HOMA-IR) (P<0.05), and was positively correlated with high-density lipoprotein cholesterol (HDL-C) (P<0.05). After adjusting age, sex, BMI, WHR, blood glucose, and blood pressure, high level fasting obestatin was correlated with intensified control of blood lipid (P<0.01). ConclusionThe fasting obestatin level is increased in T2DM patients receiving BL control compared with those do not receive, and obestatin level might be associated with lipid metabolism. |
| Key words: type 2 diabetes mellitus obestatin intensive treatment on blood lipid lipid metabolism |
