| 摘要: |
| 目的探讨肝脏转移性黑素瘤手术切除的指征和可行性。 方法和结果回顾2005年1月至2010年12月期间在我院行剖腹探查的5例肝脏转移性恶性黑素瘤患者的临床资料,并结合文献进行分析。5例眼底恶性黑素瘤转移至肝脏的患者,均行激进性手术治疗,术中发现腹腔和肝脏多发转移1例(仅行剖腹探查、肝脏活检术),肝内多发病灶4例(均行姑息性肝脏转移病灶切除术)。3例患者同期行围术期肝动脉栓塞化疗治疗。5例患者的预后均不佳，术后的平均生存时间为9.6(3～26)个月。结论肝脏转移性眼底恶性黑素瘤无法早期发现,且手术指征不明,预后较差,仍是临床上的一项治疗难题。 |
| 关键词: 眼底 黑素瘤 肝肿瘤 肿瘤转移 经导管动脉化疗栓塞术 |
| DOI：10.3724/SP.J.1008.2012.001035 |
| 投稿时间：2012-02-28修订日期：2012-04-02 |
| 基金项目: |
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| Resection of liver metastases from ocular melanoma remains discussional: an experience with 5 cases |
| YANG Xin-wei△,YANG Jue△,LU Kai,ZHANG You-lei,ZHANG Bao-hua*,SHEN Feng,WU Meng-chao |
(Department of Laparoscopy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
△Co-first authors.
*Corresponding author.) |
| Abstract: |
| ObjectiveTo investigate the indications and feasibility of resecting liver metastases from ocular melanoma. Methods and ResultsFrom Jan. 2005 to Dec. 2010, 5 patients with liver metastases from ocular melanoma were admitted to our hospital and received abdominal exploration. The clinicopathologic features and the surgical results of the 5 patients were retrospectively analyzed together with the latest literatures home and abroad. All the 5 patients received aggressive surgical managements, and simultaneous intra-arterial hepatic chemoembolization (TACE) was done in three cases. One patient received liver biopsies only after discovery of multiple visceral metastases; the other 4 with multiple liver metastases underwent palliative liver resection. All the 5 patients had poor prognoses, with a median overall postoperative survival rate of 9.6 (3-26) months. ConclusionLiver metastases from ocular melanoma are impossible to detect in an early stage. With unclear surgical indications and poor prognosis, it remains hard to handle in clinical practice. |
| Key words: fundus oculi melanoma liver neoplasms neoplasm metastasis transcatheter arterial chemoembolization |
