【打印本页】 【下载PDF全文】 【HTML】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 2052次   下载 2031 本文二维码信息
码上扫一扫!
肝前体细胞生物学特性及调控机制的研究进展
王明达,王超*,吴孟超
0
(第二军医大学东方肝胆外科医院,上海 200438
*通信作者)
摘要:
肝前体细胞(HPCs)是肝脏内具有自我更新、高度增殖和多向分化潜能的成体干细胞,不仅与肝脏再生修复密切相关,也与原发性肝癌发生、发展密切相关。本文简要总结了近几年有关肝前体细胞的生物学特性、来源、定位以及多种信号调控通路在其增殖、分化及形成肿瘤中的作用等研究进展。
关键词:  肝前体细胞  细胞分化  标志物  肝细胞癌  信号通路
DOI:10.3724/SP.J.1008.2012.001129
投稿时间:2012-05-14修订日期:2012-09-26
基金项目:
Biological characteristics and regulatory mechanisms of hepatic progenitor cells: recent progress
WANG Ming-da,WANG Chao*,WU Meng-chao
(Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438,China
*Corresponding author.)
Abstract:
Hepatic progenitor cells (HPCs) are adult stem cells with self-renewing, high proliferation and multi-directional differentiation abilities. HPCs are closely associated with liver regeneration and the development of hepatocellular carcinoma (HCC). This article reviews recent research progress in biological characteristics, source, location of HPCs and the roles of various HPCs signalings in the proliferation, differentiation and development of HCC.
Key words:  hepatic progenitor cells  cell differentiation  biomarker  hepatocellular carcinoma  signaling pathway