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开放血管平滑肌细胞Kir6.1/SUR2B降低去窦弓神经大鼠血压波动性
张伟1,赵心彬2,杨宏2,倪敏2*
0
(1.中国人民解放军总后勤部第二门诊部药房,北京 100071
2.第二军医大学长征医院药剂科,上海 200003
*通信作者)
摘要:
目的探讨心血管系统不同分子组成的ATP敏感钾通道(KATP)在降低去窦弓神经(SAD)大鼠血压波动性(BPV)中的作用。方法建立SAD大鼠模型,利用计算机化清醒自由活动大鼠血流动力学监测技术,观察非选择性KATP开放剂吡那地尔、Kir6.1/Sur2B和Kir6.1/Sur1选择性开放剂二氮嗪对SAD大鼠BPV 的影响;并观察用Kir6.1/Sur1选择性阻断剂5-羟基癸酸盐(5-HD)、Kir6.2/Sur2A选择性阻断剂HMR1098阻断KATP后,吡那地尔和二氮嗪对SAD大鼠BPV作用的改变。结果吡那地尔和二氮嗪能够降低SAD大鼠BPV(P<0.01),阻断Kir6.1/Sur1、Kir6.2/Sur2A后不改变吡那地尔和二氮嗪对BPV的降低作用。结论开放血管平滑肌细胞Kir6.1/Sur2B能够降低SAD大鼠的BPV。
关键词:  去窦弓神经  血压波动性  KATP通道  血管平滑肌
DOI:10.3724/SP.J.1008.2012.001315
投稿时间:2012-10-15修订日期:2012-12-04
基金项目:
Opening of Kir6.1/SUR2B on vascular smooth cells decreases blood pressure variability in sinoaortic denervated rats
ZHANG Wei1,ZHAO Xin-bin2,YANG Hong2,NI Min2*
(1.Department of Pharmacy, The Second Out-patient Clinics, General Logistics Department of PLA, Beijing 100071, China
2.Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
*Corresponding author.)
Abstract:
ObjectiveTo determine the role of different molecular compositions of KATP channels in reducing the blood pressure variability (BPV) in conscious,freely-moving sinoaortic denervated (SAD) rats. MethodsSAD rat model was established. Computerized analytic system of blood pressure was used to observe the effects of unselective KATP openers (pinacidil) or Kir6.1/Sur2B and Kir6.1/Sur1 selective opener (diazoxide) on BPV of SAD rats. We also observed the effects of pinacidil and diazoxide on BPV of SAD rats pre-treated with selective Kir6.1/Sur1 antagonist 5-hydroxydecanoic acid (5-HD) and selective Kir6.2/Sur2A antagonist (HMR1098). ResultsBoth pinacidil and diazoxide significantly decreased BPV in SAD rats (P<0.01), and pre-treatment with 5-HD+HMR1098 did not change the effect of either pinacidil or diazoxide on BPV of SAD rats. ConclusionOpening Kir6.1/SUR2B of vascular smooth cells can decrease the BPV levels in SAD rats.
Key words:  sinoaortic denervated  blood pressure variability  KATP channels  vascular smooth muscle