| 摘要: |
| 目的 探讨血脂与冠状动脉病变程度的相关性。方法 选择2005至2011年共4 751例经冠状动脉造影的住院患者，根据冠脉造影结果分为2组，冠脉狭窄≥50%为冠心病组（n=3 402），冠脉狭窄<50%为对照组（n=1 349）。冠心病组根据病变血管支数分为1支病变、2支病变、3支及3支以上病变3个亚组。测定患者的血清总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C），计算LDL-C/HDL-C比值。比较上述指标在各组间的差异，并采用Spearman相关分析研究LDL-C/HDL-C比值与冠状动脉病变程度之间的关系，用多元逐步logistic回归分析确定冠心病的危险因素。结果 与对照组比较，冠心病组TG、TC、LDL-C水平及LDL-C/HDL-C比值升高，HDL-C水平降低，差异均有统计学意义（P<0.01）；在冠心病组中，随着冠状动脉病变支数的增加，LDL-C/HDL-C比值逐渐升高（P<0.001），冠状动脉病变支数与LDL-C/HDL-C比值呈正相关（R=0.25，P<0.01）；多元logistic回归分析显示高LDL-C/HDL-C比值为冠心病的独立危险因素。结论 LDL-C/HDL-C比值是冠心病的独立危险因素，且与冠状动脉病变程度呈正相关。 |
| 关键词: LDL胆固醇 HDL胆固醇 脂类 冠心病 |
| DOI：10.3724/SP.J.1008.2014.00270 |
| 投稿时间：2013-10-12修订日期：2014-01-16 |
| 基金项目: |
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| Relationship between LDL-C/HDL-C and severity of coronary artery disease |
| LI Ming-chun1*,CHU Shao-li1,ZUO Jun-li1,ZENG Yi-mei2 |
(1. Department of Hypertension, Ruijin Hospital (North), Shanghai Jiaotong University School of Medicine, Shanghai 201801, China;
2. Department of Blood Transfusion, Ruijin Hospital (North), Shanghai Jiaotong University School of Medicine, Shanghai 201801, China
*Corresponding author.) |
| Abstract: |
| Objective To explore the relationship between blood lipids and the severity of coronary artery disease. Methods A total of 4 751 patients with chest pain were divided into two groups according to the results of coronary angiography: coronary artery disease group (n=3 402 stenosis in one main branch stenosis≥50%) and control group (stenosis<50%, n=1 349). According to the number of coronary artery stenosis, the coronary artery disease group was divided into three subgroups (group 1: 1 branch stenosis; group 2: 2 branch stenosis;and group 3: 3 or more than 3 branch stenosis).The serum total cholesterol (TC),triglycefides (TG),high density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were determined and LDL-C/HDL-C was calculated.The relationship between lipids and the severity of coronary artery stenosis was analyzed by Spearman correlation analysis, and the risk factors of coronary artery disease were analyzed by multiple-stepwise logistic regression analysis. Results The levels of TG, TC, LDL-C and the ratio of LDL-C/HDL-C in the coronary artery disease group were significantly lower than those in the control group (P<0.01). LDL-C/HDL-C ratio increased with the increase of diseased branches in the disease group (P<0.001), and the number of diseased branches was positively correlated with the ratio of LDL-C/HDL-C (R=0.25, P<0.01). Logistic multiple regression analysis showed that high LDL-C/HDL-C level was an independent risk factor for coronary heart disease. Conclusion LDL-C/HDL-C ratio is an independent risk factor for coronary heart disease and it is positively correlated with the severity of coronary artery lesions. |
| Key words: LDL cholesterol HDL cholesterol lipids coronary disease |
