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ATP2A2通过钙离子浓度变化参与肿瘤发生机制的研究进展
颜红柱1△,钟南哲2△,李维卿1,刘惠敏1,余宏宇1,李一明3*
0
(1.第二军医大学长征医院病理科,上海 200003
2.第二军医大学研究生管理大队2009级八年制,上海 200433
3.第二军医大学长征医院神经外科,上海 200003
共同第一作者
*通信作者)
摘要:
ATP2A2ATP2As基因家族的成员,编码肌浆(内质)网钙转运ATP酶中的一种,即SERCA2b。由于该酶的主要功能为将钙离子从胞质转运至肌浆(内质)网内,因而它在控制肿瘤生长、分化、血管生成、转移和凋亡的钙离子相关信号通路中发挥着重要作用。近期研究已在一些类型的肿瘤中明确了ATP2A2表达水平的具体变化,在探究ATP2A2是如何参与肿瘤形成以及它是否可作为肿瘤标记物和治疗靶点方面迈出了第一步。本文对ATP2A2参与肿瘤发生的可能机制的相关研究进行了总结,认为其表达异常可引起细胞胞质内和内质网间钙离子稳态的破坏,从而造成细胞的恶性增殖并促进肿瘤的迁移和血管形成等。本文还对该基因的研究和应用前景进行了展望。
关键词:  肌浆网钙转运ATP酶类  ATP2A2  钙通道  肿瘤
DOI:
投稿时间:2013-04-25修订日期:2013-06-05
基金项目:上海市自然科学基金(10ZR1439000), 国家自然科学基金(81101656/H1609,81201987/H1618).
Ca2+-dependent ATP2A2 pathway in tumorigenesis: an update
YAN Hong zhu1△,ZHONG Nan zhe2△,LI Wei qing1,LIU Hui min1,YU Hong yu1,LI Yi ming3*
(1. Department of Pathology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
2. Grade 2009, Eight Year Term, Graduate School, Second Military Medical University, Shanghai 200433, China
3. Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
Co-first authors.
*Corresponding author.)
Abstract:
ATP2A2 is a member of ATP2As family; it encodes SERCA2b,a sarco(endo)plasmic reticulum calcium transport ATPases (SERCAs). As the main function of SERCA2b is to transport calcium from the cytosol to the sarco(endo)plasmic reticulum, it plays a vital role in numerous calcium-related signaling pathways involving control of tumor growth, differentiation, angiogenesis, metastasis and apoptosis. Recent studies have identified the accurate change of ATP2A2 expression in some tumors, which makes the first step in investigating how ATP2A2 participates in tumorigenesis and whether it can be taken as a new tumor marker and target for treatment. Here we made a comprehensive review on the role of ATP2A2 in tumorigenesis, and it is believed that the abnormal expression of ATP2A2 can damage the calcium homeostasis between cytosol and sarco (endo) plasmic reticulum, accelerating malignant proliferation, migration and angiogenesis of the tumor. Moreover, we also discussed the prospect of research and application of ATP2A2.
Key words:  sarcoplasmic reticulum calcium-transporting ATPases  ATP2A2  calcium channels  neoplasms