| 摘要: |
| 目的 观察艾塞那肽对高原地区血糖控制不佳的2型糖尿病患者的疗效。方法 选择二甲双胍、磺脲类药物或胰岛素治疗后血糖控制不佳的2型糖尿病患者18例,在原有治疗方案的基础上加用艾塞那肽注射液治疗3个月,监测患者空腹血糖(FBG)、餐后2 h血糖(2hPBG)、糖化血红蛋白(HbA1c)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、体质量等指标的变化。结果 艾塞那肽治疗3个月后, 患者FBG、2hPBG、HbA1c、体质量指数,血脂TG、TC、LDL-C水平均较治疗前降低(P<0.05)。结论 艾塞那肽能有效控制高原地区2型糖尿病患者血糖, 降低患者体质量指数,并改善血脂水平。 |
| 关键词: 2型糖尿病 艾塞那肽 高海拔 血糖 |
| DOI：10.3724/SP.J.1008.2013.00341 |
| 投稿时间：2012-12-12修订日期：2013-01-21 |
| 基金项目:上海市自然科学基金(09ZR1400700). |
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| Efficiency of exenatide in treatment of type 2 diabetes mellitus patients with inadequately controlled blood glucose in plateau area |
| DENG Yong-ming1,LI Su-zhi1,CHEN Shi-xun1,LI Chuan1,ZOU Mi1,GONG Yun-bing1,HUANG Qin2,WANG Qi-jin2* |
(1. Department of Nephrology and Endocrinology, General Hospital of Tibet Military Area Command, Lhasa 850000, Tibet, China
2. Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| Objective To observe the efficiency of exenatide in treatment of type 2 diabetes mellitus patients with inadequately controlled blood glucose in plateau area. Methods Eighteen type 2 diabetes mellitus patients whose blood glucose was not well controlled by metformin, sulfonylureas or insulin therapy were selected in this study. Exenatide was added to the original therapy for 3 months, and the changes of fasting blood glucose (FBG), 2 h postprandial blood glucose (2hPBG), glycosylated hemoglobin (HbA1c), blood lipid levels (TG, TC, LDL-C, HDL-C), and body weight were observed. Results After 3 months of treatment with exenatide, FBG, 2hPBG, HbA1c, body mass index, and blood lipid levels (TG, TC, LDL-C ) were significantly reduced as compared with those before treatment (P<0.05). Conclusion Exenatide can effectively control blood glucose, decrease body mass index, and improve the blood lipid level in type 2 diabetes mellitus patients living in plateau area. |
| Key words: type 2 diabetes mellitus exenatide altitude blood glucose |
