| 摘要: |
| 目的 研究叉头框M1(forkhead box M1,FoxM1)转录因子和环氧合酶2(cyclooxygenase-2,COX-2)在鼻咽癌组织中的表达并探讨其临床意义。方法 运用免疫组织化学方法检测80例鼻咽癌组织和40例鼻咽部正常组织中FoxM1和COX-2的表达,分析其与鼻咽癌临床病理参数的关系,以及FoxM1和COX-2表达之间的关系。结果 FoxM1和COX-2在鼻咽癌组织的阳性表达率均高于鼻咽部正常组织\[FoxM1: 68.8% (55/80) vs 2.5% (1/40); COX-2: 62.5% (50/80) vs 5.0% (2/40); P<0.05\]。FoxM1阳性表达与淋巴结转移(rs=0.252,P<0.05)和临床分期(rs=0.230,P<0.05)相关；COX-2阳性表达与淋巴结转移(rs=0.287,P<0.05)和临床分期(rs=0.239,P<0.05)相关。FoxM1 与COX-2表达呈正相关(rs=0.631,P<0.05),提示二者可能有直接或间接作用关系。结论 FoxM1与COX-2在鼻咽癌组织中表达的上调可能与鼻咽癌的发生及浸润转移有关。 |
| 关键词: 鼻咽肿瘤 FoxM1 COX-2 免疫组织化学 |
| DOI：10.3724/SP.J.1008.2013.00645 |
| 投稿时间：2013-01-15修订日期：2013-03-28 |
| 基金项目: |
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| Expression of FoxM1 and COX-2 in nasopharyngeal carcinoma tissues and the related clinical significance |
| JIANG Li-zhu,1 WANG Peng2,CHEN Hong-yan3* |
(1. Department of Otolaryngology, People’s Hospital of Dazu District, Chongqing 402360, China
2. Department of Orthopedics, People’s Hospital of Dazu District, Chongqing 402360, China
3. Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
*Corresponding author.) |
| Abstract: |
| Objective To investigate the expression of forkhead box M1(FoxM1) transcription factor and cyclooxygenase-2 (COX-2) in nasopharyngeal carcinoma (NPC) tissues, and to discuss the related clinicopathological implications. Methods Immunohistochemistry method was used to examine the expression of FoxM1 and COX-2 in 80 NPC tissues and 40 normal nasopharyngeal mucosa tissues. The relationship of FoxM1 and COX-2 expression with the clinicopathological parameters of NPC was analyzed; we also analyzed the correlation between the FoxM1 and COX-2 expression. Results FoxM1 and COX-2 expressions were significantly higher in NPC tissues compared to normal nasopharyngeal mucosa tissues (FoxM1: 68.8% \[55/80\] vs 2.5% \[1/40\]; COX-2: 62.5% \[50/80\] vs 5.0% \[2/40\]; P<0.05). The expression of FoxM1 was significantly associated with lymph node metastasis (rs=0.252, P<0.05) and clinical stage of NPC (rs=0.230, P<0.05), and expression of COX-2 was also significantly associated with lymph node metastasis (rs=0.287, P<0.05) and clinical stage of NPC (rs=0.239, P<0.05). Furthermore, a positive correlation was observed between FoxM1 and COX-2 expression (rs =0.631, P<0.05), indicating a direct or indirect interaction between them. Conclusion Increased expression of FoxM1 and COX-2 in NPC tissues might be associated with the development and progression of NPC. |
| Key words: nasopharyngeal neoplams FoxM1 COX-2 immunohistochemistry |
