| 摘要: |
| 目的 分析冠心病(CAD)患者左室射血分数减低时其左颈总动脉(LCCA)瞬时波强(WI)参数值的变化特点。方法 冠状动脉造影确诊的CAD患者41例,男26例、女15例,平均年龄(59.68±7.61)岁,根据超声Simpson法测得的左室射血分数(LVEF)分为A组(LVEF＞50%,n=23例)和B组(LVEF≤50%,n=18 例)；健康体检者35例,男23例、女12例,平均年龄(61.69±13.48)岁,作为对照组(C组)。对所有受检者行常规超声心动图检查之后行LCCA二维彩色多普勒超声和WI检查,比较LVEF不同时患者LCCA的瞬时加速度波强(W1)和瞬时减速度波强(W2)值的变化及其相关性。结果 CAD 患者LCCA内-中膜厚度(IMT)较对照组明显增厚(P<0.05),W1、W2 值明显降低(P<0.05)。在CAD患者中,A组和B组的W1、W2值随着LVEF值的降低呈减低趋势,B组W1值低于A组，差异有统计学意义(P<0.05)。尤其B组中有7例LVEF<35%的患者,其W1、W2值仅为(3.32±1.91)和(1.09±0.41) mmHg/(m·s2)。在同等动脉血压水平下,所有受检者W1与W2呈正相关(r=0.41,P＜0.05),W1与LVEF间亦呈正相关(r=0.60,P＜0.05)。结论 超声WI技术所检测的LCCA W1、W2 值可以反映CAD患者左室收缩功能状态,是临床评估CAD患者外周血管血流动力学变化的一项有价值的指标。 |
| 关键词: 瞬时波强 超声检查 冠心病 左室收缩功能 |
| DOI： |
| 投稿时间：2013-02-20修订日期：2013-04-25 |
| 基金项目: |
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| Changes of common carotid artery wave intensity in coronary heart disease patients with decreased left ventricular ejection fraction |
| XU Xin-liang1,2△,WEI Wei1△,XIONG Wen-feng1,ZHAO Bao-zhen1*,LI Wei-ping1 |
(1. Department of Ultrasound, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
2. Hospital of PLA 66393 Troop, Baoding 071000, Hebei, China
△Co-first authors.
*Corresponding author.) |
| Abstract: |
| Objective To analyze the changes of wave intensity (WI) of the left common carotid artery (LCCA) in coronary artery disease (CAD) patients with decreased left ventricular ejection fraction (LVEF). Methods Forty-one CAD patients confirmed by coronary angiography (CAG) were divided into group A, LVEF >50%, 23 cases; group B, LVEF≤50%, 18 cases. The patients included 26 males and 15 females, with an average age of (59.68±7.61) years old. Normal controls (group C) had 35 participants, including 23 males and 12 females, with an average age of (61.69±13.48) years old. All the participants underwent conventional echocardiographic examination and left common carotid WI analysis (2-D color Doppler ultrasound), and the relationship and changes of the LCCA WI values were compared between group A and group B. Results The LCCA intima-media thickness (IMT) in CAD patients were significantly thicker than that in the normal controls(P<0.05), and W1 and W2 values were significantly lower than those in the normal controls (P<0.05). The W1, W2 values in group A and group B showed a decreasing trend with the decrease of LVEF values, with W1 value of group B being significantly lower than group A (P<0.05) ; especially that, for seven participants with LVEF＜35% in group B, the W1 and W2 values were only (3.32±1.91) and (1.09±0.41) mmHg/(m·s2), respectively. Under the same arterial blood pressure level, the W1 and W2 values were positively correlated with each other in all the participants of this study (r=0.41,P＜0.05), and the W1 value was positively correlated with the LVEF (r=0.60,P＜0.05). Conclusion The W1 and W2 indices of LCCA derived from carotid WI analysis can reflect the left ventricular systolic function of CAD patients, and can serve as a valuable indicator for evaluating the peripheral hemodynamic changes. |
| Key words: wave intensity ultrasonography coronary artery disease left ventricular systolic function |
