| 摘要: |
| 内皮祖细胞(endothelial progenitor cells，EPCs)自1997年被发现和认识后，改变了人们对血管生成的认知。EPCs在特定的细胞因子诱导下分化为血管内皮细胞，并参与血管新生。随着对EPCs研究的深入，其在心血管疾病发病机制和治疗方面的研究也有了重大突破。阿司匹林具有抗血小板聚集作用，被广泛应用于脑卒中、心肌梗死等心血管疾病的一级、二级预防。近年研究发现，低剂量阿司匹林通过其抗血小板聚集作用可增强EPCs功能，改善血管内皮功能，进而恢复内皮依赖性血管舒张功能。因此，了解阿司匹林对EPCs的影响及其可能的机制具有重要的临床意义。 |
| 关键词: 内皮祖细胞 阿司匹林 新生血管化 细胞运动 细胞黏附 |
| DOI： |
| 投稿时间：2013-04-03修订日期：2013-07-09 |
| 基金项目: |
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| Effects of antiplatelet drug aspirin on endothelial progenitor cells |
| LI Zhang-peng1,DENG Ya-ping1,ZHAO Ting1,NI Min2,SHEN Fu-ming1* |
(1. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
2. Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China) |
| Abstract: |
| Endothelial progenitor cells (EPCs) were discovered in 1997 and brought new insights for angiogenesis. EPCs can differentiate into mature endothelium and take part in angiogenesis. Studies have found that EPCs is a promising candidate for treating cardiovascular disease. Aspirin has antiplatelet effect and is widely used for prevention of stroke and cardiac infarction. Low dose of aspirin can improve EPCs function through antiplatelet effect, improve endothelial function, and restore the endothelium-dependent vasodilatation. Therefore it is of great significance to understand the effect of aspirin on EPCs and the related mechanisms. |
| Key words: endothelial progenitor cells aspirin neovascularization cell movement cell adhesion |
