| 摘要: |
| 【目的】探讨益肾保真方对慢性肾功能衰竭大鼠贫血的干预作用及疗效机理。【方法】采用二步5/6肾切除的方法复制慢性肾功能衰竭大鼠贫血模型，随机分为正常组、模型对照组、益肾方高、低剂量组及尿毒清组。给药6周，测定各组大鼠血肌酐、尿素氮、血红蛋白、红细胞计数、平均红细胞容积、及血清EPO含量。【结果】与模型组比较，益肾保真方组Hgb、RBC及EPO水平均显著升高，与尿毒清组比较有统计学差异（P＜0.05）； MCV无统计学差异；BUN、Scr、均显著降低，与尿毒清组比较无统计学差异。【结论】益肾保真方对肾性贫血有干预作用，其机理可能与降低氮质潴留，减轻毒素对造血的抑制；提高红细胞刺激因子EPO水平有关。 |
| 关键词: 益肾保真方 肾性贫血 EPO |
| DOI：10.3724/SP.J.1008.2014.00689 |
| 投稿时间：2013-07-16修订日期：2013-10-01 |
| 基金项目: |
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| The Experimental study that the YiShenBaoZhen Decoction’s (YSBZD) about Renal anemia rats serum EPO expression level |
| zhoudongzhi,zhanghaiyan,hanping,caolijun,yuanhui,houruijuan,zhaolisha |
| (First affiliated hospital of xi 'an jiaotong university) |
| Abstract: |
| 【Objective】To explore the YiShenBaoZhen Decoction’s (YSBZD) intervention effect to the renal anemia of chronic renal failure in rats and the mechanism of the effect of the treatment.【Methods】We produce rat model of chronic renal failure with the method of the two-step of 5/6 nephrectomy. According to completely random design principle，rats are divided into 5 groups，respectively for the normal group, the model group, the YSBZ high-dose group, YSBZ low-dose group and Niaoduqing group .Give medicine 6 weeks, to measured Scr, BUN , detected hemoglobin, the red blood cell count, the average volume of red blood cells, serum EPO.【Results】Compared with the model group, YSBZ high doses group,low doses group all can make Hgb，RBC and EPO increase,with significant difference compared with Niaoduqing group（P＜0.05）; make Scr, BUN decrease ，and compared with Niaoduqing group have no statistical significance.【Conclusion】The YSBZD can interfere with the process of the renal anemia, the mechanism of which may be: reducing nitrogen retention, and reducing the toxin on the inhibition of hematopoietic system; increasing factor about stimulating synthesis of red blood cells. |
| Key words: YiShenBaoZhen Decoction renal anemia erythropoietin |
