| 摘要: |
| 目的：颅内动脉瘤模型绝大多数为小动物，不利于血流动力学及血管内治疗研究。本研究通过结扎新西兰大白兔双侧颈总动脉，诱导基底动脉顶端动脉瘤生成。方法：新西兰大白兔26只，分别游离双侧颈总动脉，不行结扎或结扎双侧颈总动脉以增加基底动脉血流。分别于结扎前（0d）、术后1d、1w、4w经颅多普勒测量基底动脉血流速度。术后4w行脑血管造影了解基底动脉变化；术后1w、4w取基底动脉观察动脉形态变化及分叉部行组织学检查。结果：假手术组动物全部成活，实验组术后存活率80%（16/20）。实验组术后1d，基底动脉血流速度直线升高，高于术前231%；术后1w仍在持续升高；术后4w血流速度处于稳定状态。实验组术后1w，基底动脉增粗，明显迂曲；而假手术组无明显变化。实验组基底动脉分叉部中膜厚度变薄；内弹力层部分消失、断裂或变薄。结论：新西兰大白兔双侧颈总动脉结扎术后，基底动脉分叉部血流增加导致基底动脉形态发生改变，并且诱导基底动脉顶端呈现新生动脉瘤样改变。 |
| 关键词: 颅内动脉瘤 模型 血流动力学 基底动脉 |
| DOI：10.3724/SP.J.1008.2014.00438 |
| 投稿时间：2013-08-13修订日期：2013-10-31 |
| 基金项目:国家自然科学基金 |
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| Basilar terminus aneurysm model of rabbit induced by hemodynamic changes |
| Yao Pengfei,Yang Pengfei,Zhang Zhaolong,Huang Qinghai,Liu Jianmin |
| (Department of Neurosurgery, Changhai Hospital, Second Military Medical University) |
| Abstract: |
| Objective Most of intracranial aneurysm models were small animals, which were not conducive to study on hemodynamics and endovascular therapy. This study induced the aneurysm formation at the basilar terminus by ligation of the bilateral common carotid artery of the New Zealand white rabbit. Methods Twenty six adult New Zealand white rabbits were subjected to sham, or bilateral common carotid artery ligation to produce basilar artery flow increase. Basilar artery flow velocity was monitored by transcranial Doppler, before the operation, and 1d, 1w, 4 weeks after surgery. Cerebral angiography was performed 4 weeks after surgery. The basilar arterys were seperated and compared morpholodical changes. Bifurcation tissues were harvested at 4 weeks and examined histologically. Results All animals survived in the sham group, and 80% ( 16 /20 ) survived in the experimental group. Subsequent to bilateral common carotid artery ligation, basilar artery flow velocity increased straightly, by 231% compared with the preoperation. The flow velocity kept on increasing 1 w after the operation and it was in a stable state after 4 weeks. The basal arteries augmented obviously and displayed tortuous in the experimental group. But there was no such change in the sham. All common carotid artery-ligated rabbits presented with thinned media and absent，rupture or thinned internal elastic lamina near the basilar terminus. Conclusion After the ligation of the bilateral common carotid arteries of New Zealand white rabbit, flow increase at the basilar bifurcation can lead to a change of the basilar artery morpholog and induced a nascent aneurysm in the basilar terminus. |
| Key words: intracranial aneurysm model hemodynamics basilar artery |
