| 摘要: |
| 非酒精性脂肪肝（non-alcoholic fatty liver disease，NAFLD）的发病率日益增多，迄今为止尚没有确切有效的治疗措施。目前的研究主要针对NAFLD及代谢障碍的分子机制，包括核转录因子孕烷X受体(pregnane X receptor，PXR)、叉头蛋白O1（forkhead box protein O1 FOXO1）、类法尼醇X受体 (farnesoid X receptor, FXR)、过氧化物酶体增殖物激活受体（peroxisome proliferator-activated receptors，PPARs）、甲状腺激素受体（thyroid hormone receptor,THR）、腺苷酸活化蛋白激酶（AMP-activated protein kinase，AMPK）、p53、核因子E2相关因子2（Nuclear erythroid 2-related factor 2，Nrf2）、线粒体、大麻素受体和胆汁酸受体等。本文主要就这些分子机制作一综述，探讨这些靶点的潜在治疗价值。 |
| 关键词: 非酒精性脂肪肝、核转录因子、分子机制 |
| DOI：10.3724/SP.J.1008.2014.00657 |
| 投稿时间：2013-08-19修订日期：2014-03-19 |
| 基金项目:国家自然科学基金 |
|
| Molecular target of NAFLD intervention |
| 黄玥晔,Qu Shen |
| (Department of Endocrinology Shanghai 10th People’s Hospital) |
| Abstract: |
| The incidence of non-alcoholic fatty liver disease（NAFLD） is increasing nowadays. Until now there is still no effective treatment of NAFLD, and most researcheshave focused on molecular mechanisms of NAFLD andmetabolic disorders. This review discusses these new molecular mechanisms and their potential treatment of NAFLD, including PXR（pregnane X receptor），FOXO1(forkhead box protein O1)、FXR（farnesoid X receptor），PPARs（peroxisome proliferator-activated receptors），THR（thyroid hormone receptor），AMPK(AMP-activated protein kinase) ，p53,Nrf2(Nuclear erythroid 2-related factor 2)，mitochondria，cannabinoid receptors，and bile-acid receptor. |
| Key words: non-alcoholic fatty liver disease nuclear transcription factor molecular mechanisms |
