| 摘要: |
| 目的 研究宽叶缬草（Valeriana officinalis Linn. var. latiofolia Miq.）根的水溶性化学成分。方法 利用大孔树脂Diaion HP-20柱色谱、硅胶柱色谱、Sephadex LH-20柱色谱等手段对宽叶缬草根的水溶性成分进行分离纯化，应用质谱、1D核磁共振光谱（NMR）、2D NMR等方法对分得的化合物进行结构鉴定。结果和结论 从宽叶缬草根中分离并鉴定了13个化合物，分别为甘西鼠尾甲苷A（1）、当归棱子芹醇葡萄糖苷（2）、（-）-当归棱子芹醇-2-O-β-D-呋喃芹菜糖基-（1→6）-β-D-吡喃葡萄糖苷（3）、6-羟基-7-羟甲基-4-亚甲基六氢环戊骈吡喃-1（3H）-酮（4）、缬草苷A（5）、双四氢呋喃木脂素-4-O-β-D-吡喃葡萄糖苷（6）、（+）-松脂酚-4-O-β-D-吡喃葡萄糖苷（7）、小蜡苷Ⅰ（8）、青木香苷A（9）、（+）-1-羟基松脂酚-1-O-β-D-葡萄糖苷（10）、（+）-松脂酚-4，4’-O-二吡喃葡萄糖苷（11）、（+）-环橄榄脂素-6-O-β-D-吡喃葡萄糖苷（12）、松柏苷（13）。所有化合物均为首次从该植物中分离得到。 |
| 关键词: 宽叶缬草 化学成分 单萜苷 环烯醚萜类 木脂素苷 |
| DOI：10.3724/SP.J.1008.2014.00161 |
| 投稿时间：2013-08-28修订日期：2013-10-14 |
| 基金项目:国家自然科学基金（81102335），上海市科委启明星计划（11QA1408200），上海活性天然产物制备工程技术研究中心（10DZ2251300）. |
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| Water soluble chemical constituents of Valeriana officinalis Linn. var. latiofolia Miq. |
| ZU Xian-peng,ZHANG Wei-dong,HAN Zhu-zhen,LI Hui-liang* |
(Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
*通信作者) |
| Abstract: |
| Objective To investigate the water soluble chemical constituents in the root of Valeriana officinalis Linn. var. latiofolia Miq. and to identify their structures. Methods The water soluble chemical constituents were isolated and purified by macroporous resin Diaion HP-20, silica gel and Sephadex LH-20; the chemical structures of the components were determined by MS, 1D NMR and 2D NMR spectral analysis. Results and conclusion Thirteen constituents were isolated and identified from the root of Valeriana officinalis Linn. var. latiofolia, including Ganxinoside A (1), (-)-angelicoidenol-2-O-β-D-glucopyranoside (2), (-)-angelicoidenol-2-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (3), 6-hydroxy-7-(hydroxymethyl)-4-methylenehexahydrocyclopenta[c]pyran-1 (3H)-one (4), kanokoside A (5), prinsepiol-4-O-β-D-glucopyranoside (6), (+)-pinoresinol-4-O-β-D-glucopyranoside (7), sinenoside Ⅰ (8), lanicepsides A (9), (+)-1-hydroxypinoresinol-1-O-β-D-glucoside (10), (+)-pinoresinol-4, 4'-O-bisglucopyranoside (11), (+)-cycloolivil 6-O-β-D-glucopyranoside (12), and coniferin (13). All the 13 compounds are isolated from the root of Valeriana officinalis Linn. var. latiofolia Miq. for the first time. |
| Key words: Valeriana officinalis Linn. var. latiofolia Miq. chemical constituents monoterpenoid glucoside iridoids lignin glycosides |
