| 摘要: |
| 多发性硬化症既是经典的神经免疫性疾病，又是神经退行性疾病。越来越多的证据表明，表观遗传学改变与多发性硬化症的发病相关。表观遗传学修饰可以影响基因的表达，但不会改变DNA的序列。DNA甲基化、组蛋白修饰和微小RNA相关基因转录和翻译的调控是表观遗传的3种重要机制。表观遗传学可能通过调节多发性硬化症的病因（包括遗传易感性和环境危险因素）和发病机制（包括炎症脱髓鞘和神经退行性变化的机制）的多个环节影响多发性硬化症的发病。本文综述了表观遗传学修饰在多发性硬化症发生中的作用，并为从表观遗传学角度治疗多发性硬化症提出建议。 |
| 关键词: 表观遗传学 多发性硬化 DNA甲基化 组蛋白类 微RNAs |
| DOI：10.3724/SP.J.1008.2014.00774 |
| 投稿时间：2013-10-28修订日期：2014-01-16 |
| 基金项目: |
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| Role of epigenetic modification in multiple sclerosis：an advance |
| ZHAO Ming,CAO Li* |
(Department of Neurobiology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| Multiple sclerosis (MS) is a classic neuroimmunologic and neurodegenerative disease. A growing body of evidence suggests that epigenetic changes are associated with the development of MS. Epigenetic modifications can influence the expression of genes, but will not change the sequence of DNA. DNA methylation, histone modification and microRNA-associated post-transcriptional gene silencing are three key epigenetic mechanisms that influence gene expression. Epigenetic mechanisms may regulate MS onset by affecting the genetic susceptibility and environmental risk factors, and by influencing the inflammatory demyelination and neurodegeneration involved in MS pathology. In this review we summarized recent studies on the role of epigenetic changes in the pathophysiology and treatment of MS. |
| Key words: epigenetic multiple sclerosis DNA methylation histones microRNAs |
