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EML4-ALK融合基因与非小细胞肺癌中的研究进展
赵静,郑建明,余永伟
0
(第二军医大学附属长海医院;第二军医大学附属长海医院病理科)
摘要:
棘皮动物微管结合蛋白4(echinoderm microtubule associated protein-like 4,EML4)与间变淋巴瘤激酶(anaplastic lymphoma kinase,ALK)形成的融合基因被认为是非小细胞肺癌(NSCLC)新的分子靶点。该融合基因在年轻,不吸烟或少吸烟,腺癌的非小细胞肺癌患者中发生率较高。本综述重点阐述NSLCL中EML4-ALK的生物学特性,检测方法,临床特征和治疗。
关键词:  非小细胞肺癌;EML4-ALK  融合基因
DOI:10.3724/SP.J.1008.2014.00898
投稿时间:2013-11-06修订日期:2014-07-01
基金项目:
Reseach progress of EML4-ALK Fusion Gene in Non-small Cell Lung Cancer
赵静,zhengjianming,yuyongwei
(Department of Pathology, Affiliated Changhai Hospital of Second Military Medical University, Shanghai)
Abstract:
The fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase(ALK) has recently been identified as a new molecular target of non-small cell lung cancers(NSCLC).The fusion gene has higher morbidity in NSCLC patients who are young , never or light smoking history and adenocarcinomas.This review emphasizes the biological,detection method,clinical characteristics and the therapeutic application of EML4-ALK in NSCLC.
Key words:  Non-small cell lung cancer  EML4-ALK  fusion oncogene