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| 肉芝软珊瑚属中二萜类化合物的化学及生物活性 |
| 俞庆1,2,孙鹏2,刘宝姝2,汤华2,张文1,2* |
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(1. 安徽中医药大学药学院, 合肥 230038;
2. 第二军医大学药学院海洋药物研究中心, 上海 200433
*通信作者) |
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| 摘要: |
| 二萜类化合物是肉芝软珊瑚（Sarcophyton）的特征性次生代谢产物，其多变的化学结构及广泛的生物学活性引起了化学及药理学研究领域的广泛关注，已成为海洋天然产物的研究热点之一。1997年印度学者对肉芝软珊瑚相关研究已经进行了较为详细的综述，本文对该属珊瑚1998年之后的研究进展进行了总结，包括来自12种已鉴定和13种未鉴定珊瑚的143个化合物，涵盖了1998年至今的54篇文献。 |
| 关键词: 肉芝软珊瑚 二萜类 分子结构 生物活性 |
| DOI：10.3724/SP.J.1008.2014.00206 |
| 投稿时间：2013-11-29修订日期：2014-01-02 |
| 基金项目:国家自然科学基金面上项目（81172979），国家高技术研究发展计划（“863”计划，2013AA092902）. |
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| Chemistry and bioactivity of diterpenoids in soft corals of genus Sarcophyton：recent progress |
| YU Qing1,2,SUN Peng2,LIU Bao-shu2,TANG Hua2,ZHANG Wen1,2* |
(1. School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230038, Anhui, China;
2. Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| Diterpenoids are the characteristic secondary metabolites of the soft corals of the genus Sarcophyton. The intriguing structure and broad spectrum of bioactivity of these metabolites have drawn great attention from the chemistry and pharmacology fields, and they have become a focus of study in marine natural products. In 1997 Indian researchers reviewed the related studies of the soft corals of the genus Sarcophyton. This paper summarizes the research progress in 12 identified and 13 unidentified species of this genus reported in 54 citations published from 1998 to the Oct. of 2013, involving 143 compounds. |
| Key words: Sarcophyton diterphenes molecular structure bioactivity |
